A simple method for the synthesis of 4-aryl-9-oxynaphthofuranone lignans

被引：16

作者：

Kobayashi, K

Maeda, K

Uneda, T

Morikawa, O

Konishi, H

机构：

[1] Department of Materials Science, Faculty of Engineering, Tottori University

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1997年 / 04期

关键词：

D O I：

10.1039/a605288f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 9-aryl-4-oxynaphthofuran-1(3H)-one system is generally synthesized in two steps from alpha-aryl-o-toluic acid derivatives. The method involves a tandem conjugate addition-Dieckmann type condensation between alpha-lithiated alpha-aryl-o-toluic acid derivatives and 2-furan-2(5H)-one as a key step followed by simple dehydrogenation or dehydration, and can be applied to the synthesis of two natural lignans (neojusticidin A and neojusticidin B).

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页码：443 / 446

页数：4

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