Natural and synthetic G-quadruplex interactive berberine derivatives

被引：194

作者：

Franceschin, M

Rossetti, L

D'Ambrosio, A

Schirripa, S

Bianco, A

Ortaggi, G

Savino, M

Schultes, C

Neidle, S

机构：

[1] Univ London, Sch Pharm, Canc Res UK Biomol Struct Grp, London WC1N 1AX, England

[2] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy

[3] Univ Roma La Sapienza, Dipartimento Genet & Biol Mol, I-00185 Rome, Italy

[4] Univ Roma La Sapienza, Scuola Specializzaz Sostanze Organ Nat Luigi Pani, I-00185 Rome, Italy

[5] Univ Roma La Sapienza, CNR, Ist Biol & Patol Mol, I-00185 Rome, Italy

[6] Univ Roma La Sapienza, CNR, Ist Chim Biomol, I-00185 Rome, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 06期

关键词：

G-quadruplex; telomerase; alkaloid; berberine;

D O I：

10.1016/j.bmcl.2005.12.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The interaction of the natural alkaloid berberine with various G-quadruplex DNA structures and its ability to inhibit telomerase have been examined and compared with those of a synthetic piperidino derivative and the related compound coralyne. The results show that these molecules have selectivity for G-quadruplex compared to duplex DNA, and that their aromatic moieties play a dominant role in quadruplex binding. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1707 / 1711

页数：5

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[1] Telomerase: a potential therapeutic target for cancer [J].