Solid state characterisation of silver sulfadiazine loaded on montmorillonite/chitosan nanocomposite for wound healing

被引：79

作者：

Aguzzi, Carola ^{[1
]}

Sandri, Giuseppina ^{[2
]}

Bonferoni, Cristina ^{[2
]}

Cerezo, Pilar ^{[1
]}

Rossi, Silvia ^{[2
]}

Ferrari, Franca ^{[2
]}

Caramella, Carla ^{[2
]}

Viseras, Cesar ^{[1
,3
]}

机构：

[1] Univ Granada, Sch Pharm, Dept Pharm & Pharmaceut Technol, E-18071 Granada, Spain

[2] Univ Pavia, Dept Drug Sci, I-27100 Pavia, Italy

[3] CSIC Univ Granada, Andalusian Inst Earth Sci, Armilla 18100, Granada, Spain

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2014年 / 113卷

关键词：

Montmorillonite; Chitosan; Nanocomposites; Silver sulfadiazine; Solid state characterisation; BIOPOLYMER-CLAY NANOCOMPOSITES; DRUG-DELIVERY; CHITOSAN; BIOCOMPATIBILITY; NANOPARTICLES; INFECTIONS;

D O I：

10.1016/j.colsurfb.2013.08.043

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 [生物物理学];

摘要：

Biopolymer chitosan/montmorillonite nanocomposites loaded with silver sulfadiazine for wound healing purposes were prepared via intercalation solution technique. Structure and morphology of loaded nanocomposites were studied and compared with pure components and unloaded nanocomposites. X-ray diffraction, Fourier transformed infrared spectroscopy, high resolution transmission electron microscopy coupled with energy-dispersion X-ray analysis, thermal and elemental analysis were employed for the characterisation. The results confirmed that the drug was effectively loaded in the three-dimensional nanocomposite structures, in which chitosan chains were adsorbed in monolayers into the clay mineral interlayer spaces. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：152 / 157

页数：6

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