Human Adipose-Derived Stem Cells Impair Natural Killer Cell Function and Exhibit Low Susceptibility to Natural Killer-Mediated Lysis

被引：94

作者：

DelaRosa, Olga ^{[1
]}

Sanchez-Correa, Beatriz ^{[2
]}

Morgado, Sara ^{[2
]}

Ramirez, Cristina ^{[1
]}

del Rio, Borja ^{[1
]}

Menta, Ramon ^{[1
]}

Lombardo, Eleuterio ^{[1
]}

Tarazona, Raquel ^{[2
]}

Casado, Javier G. ^{[2
]}

机构：

[1] Cellerix SA, Tres Cantos, Spain

[2] Univ Extremadura, Immunol Unit, Dept Physiol, Caceres, Spain

来源：

STEM CELLS AND DEVELOPMENT | 2012年 / 21卷 / 08期

关键词：

NK-ASSOCIATED RECEPTORS; COMPLEX PERIANAL FISTULA; MARROW STROMAL CELLS; T-CELLS; INDOLEAMINE 2,3-DIOXYGENASE; DIFFERENTIATION; EXPRESSION; TISSUE; IDENTIFICATION; MELANOMA;

D O I：

10.1089/scd.2011.0139

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Human adipose-derived stem cells (hASCs) have been successfully used in treating numerous diseases. However, several aspects need to be considered, particularly in the context of allogeneic cell therapy. To better understand hASCs-host interactions, we studied the phenotype of hASCs and their modulatory effect on natural killer (NK) cells by using bone marrow-mesenchymal stem cells (hBM-MSCs) as a reference. The hASCs displayed a lower susceptibility to NK cell-mediated lysis and a lower expression of ligands for DNAM-1 when compared with hBM-MSCs. Moreover, here we demonstrated that hASCs and hBM-MSCs can modulate NK cells through the action of soluble factors such as indoleamine 2,3-dioxygenase. Altogether, these results suggest that for an adoptive cell therapy based on the transfer of allogeneic hASCs, the NK-hASCs crosstalk will not result in an immediate recognition of the transferred cells. Thus, hASCs may remain in the tissue long enough to balance the immune response before being cleared.

引用

页码：1333 / 1343

页数：11

共 56 条

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