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Brain effects of TMS delivered over prefrontal cortex in depressed adults: Role of stimulation frequency and coil-cortex distance

被引：120
作者：
Nahas, Z
Teneback, HC
Kozel, A
Speer, AM
DeBrux, C
Molloy, M
Stallings, L
Spicer, KM
Arana, G
Bohning, DE
Risch, SC
George, MS
机构：
[1] Med Univ S Carolina, Dept Radiol, Funct Neuroimaging Res Div, Brain Simulat Lab, Charleston, SC 29425 USA
[2] Med Univ S Carolina, Dept Psychiat, Funct Neuroimaging Res Div, Brain Simulat Lab, Charleston, SC 29425 USA
[3] Med Univ S Carolina, Dept Neurol, Funct Neuroimaging Res Div, Brain Simulat Lab, Charleston, SC 29425 USA
[4] Ralph H Johnson Vet Hosp, Charleston, SC USA
来源：
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2001年 / 13卷 / 04期
关键词：
D O I：
10.1176/appi.neuropsych.13.4.459
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Relative regional brain blood flow was measured in 23 clinically depressed adults by using ECD SPECT at baseline and again during actual prefrontal transcranial magnetic stimulation (TMS) following 5 daily sessions of TMS. TMS over prefrontal cortex caused increased activity in cortex directly under the stimulation (inversely correlated with distance from scalp to cortex) and decreased activity in remote regions (anterior cingulate and anterior temporal poles). High-frequency rTMS (20 Hz) caused more relative flow immediately below the TMS coil than did low-frequency rTMS (5 Hz). Confirming the hypotheses tested, repeated daily TMS over the prefrontal cortex in medication-free depressed adults appears to change both local and remote blood flow in a manner that may also depend on the frequency of stimulation and coil to outer cortex distance.
引用
收藏
页码：459 / 470
页数：12
相关论文
共 61 条
[1]   PARALLEL ORGANIZATION OF FUNCTIONALLY SEGREGATED CIRCUITS LINKING BASAL GANGLIA AND CORTEX [J].
ALEXANDER, GE ;
DELONG, MR ;
STRICK, PL .
ANNUAL REVIEW OF NEUROSCIENCE, 1986, 9 :357-381
[2]  
[Anonymous], 2000, TRANSCRANIAL MAGNETI
[3]   Homosynaptic long-term depression: A mechanism for memory? [J].
Bear, MF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (17) :9457-9458
[4]   A randomized clinical trial of repetitive transcranial magnetic stimulation in the treatment of major depression [J].
Berman, RM ;
Narasimhan, M ;
Sanacora, G ;
Miano, AP ;
Hoffman, RE ;
Hu, XS ;
Charney, DS ;
Boutros, NN .
BIOLOGICAL PSYCHIATRY, 2000, 47 (04) :332-337
[5]   A combined TMS/fMRI study of intensity-dependent TMS over motor cortex [J].
Bohning, DE ;
Shastri, A ;
McConnell, KA ;
Nahas, Z ;
Lorberbaum, JP ;
Roberts, DR ;
Teneback, C ;
Vincent, DJ ;
George, MS .
BIOLOGICAL PSYCHIATRY, 1999, 45 (04) :385-394
[6]   Impaired inhibition in writer's cramp during voluntary muscle activation [J].
Chen, R ;
Wassermann, EM ;
Canos, M ;
Hallett, M .
NEUROLOGY, 1997, 49 (04) :1054-1059
[7]   Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation [J].
Chen, R ;
Classen, J ;
Gerloff, C ;
Celnik, P ;
Wassermann, EM ;
Hallett, M ;
Cohen, LG .
NEUROLOGY, 1997, 48 (05) :1398-1403
[8]  
DHUNA AK, 1990, ANN NEUROL, V28, P264
[9]   The use of rapid-rate transcranial magnetic stimulation (rTMS) in refractory depressed patients [J].
Figiel, GS ;
Epstein, C ;
McDonald, WM ;
Amazon-Leece, J ;
Figiel, L ;
Saldivia, A ;
Glover, S .
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, 1998, 10 (01) :20-25
[10]   Imaging human intra-cerebral connectivity by PET during TMS [J].
Fox, P ;
Ingham, R ;
George, MS ;
Mayberg, H ;
Ingham, J ;
Roby, J ;
Martin, C ;
Jerabek, P .
NEUROREPORT, 1997, 8 (12) :2787-2791
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