Mixed effects models with censored data with application to HIV RNA levels

被引：181

作者：

Hughes, JP ^{[1
]}

机构：

[1] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

来源：

BIOMETRICS | 1999年 / 55卷 / 02期

关键词：

censored data; EM algorithm; Gibbs sampling; laboratory detection limits; mixed effects models; variance components;

D O I：

10.1111/j.0006-341X.1999.00625.x

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mixed effects models are often used for estimating fixed effects and variance components in longitudinal studies of continuous data. When the outcome being modelled is a laboratory measurement, however, it may be subject to lower and upper detection limits (i.e., censoring). In this paper, the usual EM estimation procedure for mixed effects models is modified to account for left and/or right censoring.

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收藏

页码：625 / 629

页数：5

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