Regulated phosphorylation of the RNA polymerase IIC-terminal domain (CTD)

被引：43

作者：

Bensaude, O ^{[1
]}

Bonnet, F ^{[1
]}

Cassé, C ^{[1
]}

Dubois, MF ^{[1
]}

Nguyen, VT ^{[1
]}

Palancade, B ^{[1
]}

机构：

[1] Ecole Normale Super, Genet Mol Lab, F-75230 Paris 05, France

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 1999年 / 77卷 / 04期

关键词：

RNA polymerase II; phosphorylation; transcription inhibitors; cyclin-dependent kinases; development;

D O I：

10.1139/bcb-77-4-249

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The largest subunit of RNA polymerase II has an intriguing feature in its carboxyl-terminal domain (CTD) that consists of multiple repeats of an evolutionary conserved motif of seven amino acids. CTD phosphorylation plays a pivotal role in controlling mRNA synthesis and maturation. In exponentially growing cells, the phosphate turnover on the CTD is fast; it is blocked by common inhibitors of transcription, such as 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole and actinomycin D. Transcription-independent changes in CTD phosphorylation are observed at critical developmental stages, such as meiosis and early development.

引用

页码：249 / 255

页数：7

共 68 条

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