Genetic variation in hepatitis B virus

被引：7

作者：

Harrison, TJ

机构：

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 1996年 / 8卷 / 04期

关键词：

precore mutant; encapsidation signal; a determinant; antibody escape variants;

D O I：

10.1097/00042737-199604000-00003

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In wild type isolates of hepatitis B virus (HBV), the sequence of the genome may vary in up to 10% of nucleotide positions despite conservation of coding and function. Changes as small as of a single base, however, may disrupt expression of viral proteins. For example, precore mutants fail to synthesize HBeAg and point mutations in the region encoding the a determinant of HBsAg may have a profound effect on antigenicity. Investigation of HBV sequences in virus from patients with unusual serological profiles continues to reveal novel variants.

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页码：306 / 311

页数：6

相关论文

共 48 条

[1] SPECIFIC DELETIONS IN THE HEPATITIS-B VIRUS CORE OPEN READING FRAME IN PATIENTS WITH CHRONIC ACTIVE HEPATITIS-B [J].

ACKRILL, AM ;

NAOUMOV, NV ;

EDDLESTON, ALWF ;

WILLIAMS, R .

JOURNAL OF MEDICAL VIROLOGY, 1993, 41 (02) :165-169

[2] MOLECULAR CHARACTERIZATION OF A NEW VARIANT OF HEPATITIS-B VIRUS IN A PERSISTENTLY INFECTED HOMOSEXUAL MAN [J].

BHAT, RA ;

ULRICH, PP ;

VYAS, GN .

HEPATOLOGY, 1990, 11 (02) :271-276

[3] NATURALLY-OCCURRING MISSENSE MUTATION IN THE POLYMERASE GENE TERMINATING HEPATITIS-B VIRUS-REPLICATION [J].

BLUM, HE ;

GALUN, E ;

LIANG, TJ ;

VONWEIZSACKER, F ;

WANDS, JR .

JOURNAL OF VIROLOGY, 1991, 65 (04) :1836-1842

[4] PERSISTENCE OF HEPATITIS-B VIRAL-DNA AFTER SEROLOGICAL RECOVERY FROM HEPATITIS-B VIRUS-INFECTION [J].

BLUM, HE ;

LIANG, TJ ;

GALUN, E ;

WANDS, JR .

HEPATOLOGY, 1991, 14 (01) :56-62

[5] A NEW HEPATITIS-B VIRUS-STRAIN IN PATIENTS WITH SEVERE ANTI-HBE POSITIVE CHRONIC HEPATITIS-B [J].

BRUNETTO, MR ;

STEMLER, M ;

BONINO, F ;

SCHODEL, F ;

OLIVERI, F ;

RIZZETTO, M ;

VERME, G ;

WILL, H .

JOURNAL OF HEPATOLOGY, 1990, 10 (02) :258-261

[6] PRECORE SEQUENCE VARIATION IN CHINESE ISOLATES OF HEPATITIS-B VIRUS [J].

CARMAN, WF ;

FERRAO, M ;

LOK, ASF ;

MA, OCK ;

LAI, CL ;

THOMAS, HC .

JOURNAL OF INFECTIOUS DISEASES, 1992, 165 (01) :127-133

[7] VACCINE-INDUCED ESCAPE MUTANT OF HEPATITIS-B VIRUS [J].

CARMAN, WF ;

ZANETTI, AR ;

KARAYIANNIS, P ;

WATERS, J ;

MANZILLO, G ;

TANZI, E ;

ZUCKERMAN, AJ ;

THOMAS, HC .

LANCET, 1990, 336 (8711) :325-329

[8]

CARMAN WF, 1989, LANCET, V2, P588

[9] ASSOCIATION OF A PRECORE GENOMIC VARIANT OF HEPATITIS-B VIRUS WITH FULMINANT-HEPATITIS [J].

CARMAN, WF ;

FAGAN, EA ;

HADZIYANNIS, S ;

KARAYIANNIS, P ;

TASSOPOULOS, NC ;

WILLIAMS, R ;

THOMAS, HC .

HEPATOLOGY, 1991, 14 (02) :219-222

[10] THE WOODCHUCK HEPATITIS VIRUS-X GENE IS IMPORTANT FOR ESTABLISHMENT OF VIRUS-INFECTION IN WOODCHUCKS [J].

CHEN, HS ;

KANEKO, S ;

GIRONES, R ;

ANDERSON, RW ;

HORNBUCKLE, WE ;

TENNANT, BC ;

COTE, PJ ;

GERIN, JL ;

PURCELL, RH ;

MILLER, RH .

JOURNAL OF VIROLOGY, 1993, 67 (03) :1218-1226

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