Anthropometric Characteristics and Risk of Uterine Leiomyoma

被引：48

作者：

Terry, Kathryn L. ^{[1
,2
,3
]}

De Vivo, Immaculata ^{[1
,2
]}

Hankinson, Susan E. ^{[1
,2
]}

Spiegelman, Donna ^{[2
,4
]}

Wise, Lauren A. ^{[5
]}

Missmer, Stacey A. ^{[1
,2
,3
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Channing Lab, Boston, MA 02115 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[3] Harvard Univ, Brigham & Womens Hosp, Dept Obstet & Gynecol, Boston, MA 02115 USA

[4] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[5] Boston Univ, Sch Publ Hlth, Slone Epidemiol Ctr, Boston, MA USA

来源：

EPIDEMIOLOGY | 2007年 / 18卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1097/EDE.0b013e3181567eed

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: The etiology of uterine leiomyoma ( or fibroids) is poorly understood. Sex steroid hormones and growth factors have been hypothesized to play a role in their development, and anthropometric characteristics may influence uterine leiomyoma risk. Methods: We analyzed prospectively-collected data from the Nurses' Health Study II, a cohort of 116,609 female registered nurses age 25 to 42 years at baseline. Incidence of uterine leiomyoma and anthropometric characteristics were assessed every 2 years. We calculated hazard ratios and 95% confidence intervals adjusted for known and suspected risk factors for uterine leiomyoma. Results: Uterine leiomyomas were associated with current body mass index, change in weight since age 18, and waist-to-hip ratio. However, there was little evidence of their association with body mass index at age 18, childhood or adolescent body size, or adult height. Conclusion: Body mass and weight gain in adulthood may increase the risk of uterine leiomyoma, but body mass in early life does not.

引用

页码：758 / 763

页数：6

共 31 条

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