Differential transmission of type 1 diabetes from diabetic fathers and mothers to their offspring

被引:59
作者
Harjutsalo, V
Reunanen, A
Tuomilehto, J
机构
[1] Natl Publ Hlth Inst, Diabet & Genet Epidemiol Unit, Dept Epidemiol & Hlth Promot, FIN-00300 Helsinki, Finland
[2] Natl Publ Hlth Inst, Dept Hlth & Funct Capac, FIN-00300 Helsinki, Finland
[3] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland
[4] S Ostrobthnia Cent Hosp, Seinajoki, Finland
关键词
D O I
10.2337/db05-1296
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We studied the incidence of type I diabetes in the offspring of patients with childhood- and adolescent-onset type 1 diabetes and several risk factors predicting the risk. We defined the diabetes status in the offspring of all probands who were included in the nationwide register of Finnish type 1 diabetic patients diagnosed at the age of :517 years from 1965 to 1979. A total of 5,291 offspring at risk contributed 72,220 person-years of follow-up between 1970 and 2003. Of them, 259 offspring developed type 1 diabetes by the end of 2003, giving a cumulative incidence of 6.7% (95% CI 5.9-7.5) by the age of 20 years. The incidence of type I diabetes in the offspring between the years 1980 and 2003 was 35.3, 44.6, and 44.6 per 10,000 person-years for the age-groups 0-4, 5-9, and 10-14 years, respectively. Poisson regression analyses showed a marked increase in incidence of 5.3% per year from 1983 to 2003. The greatest increase occurred in the youngest offspring, aged 0-4 years. Of the offspring of male probands, 7.8% were affected by the age of 20 years compared with 5.3% of the offspring of female probands (relative risk 1.7 [95% CI 1.3-2.2]). The young age at onset of diabetes increased the risk of type 1 diabetes in the offspring of diabetic fathers but not in the offspring of diabetic mothers. In conclusion, our findings revealed that in the offspring of type 1 diabetic patients, the increase in the recurrence risk of type I diabetes was not more rapid compared with that in the background population. In the multivariate analyses, statistically significant predictors of type 1 diabetes in the offspring were male sex of the diabetic parent, young age at diagnosis in the male parent, and the more recent year of birth of the offspring.
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页码:1517 / 1524
页数:8
相关论文
共 33 条
  • [1] DECREASED RISK OF TYPE-I DIABETES IN OFFSPRING OF MOTHERS WHO ACQUIRE DIABETES DURING ADRENARCHY
    BLEICH, D
    POLAK, M
    EISENBARTH, GS
    JACKSON, RA
    [J]. DIABETES, 1993, 42 (10) : 1433 - 1439
  • [2] Incidence data of childhood-onset type I diabetes in France during 1988-1997:: The case for a shift toward younger age at onset
    Charkaluk, ML
    Czernichow, P
    Lévy-Marchal, C
    [J]. PEDIATRIC RESEARCH, 2002, 52 (06) : 859 - 862
  • [3] DAHLQUIST G, 1989, DIABETOLOGIA, V32, P2
  • [4] Temporal trends in spontaneous abortion associated with Type 1 diabetes
    Dorman, JS
    Burke, JP
    McCarthy, BJ
    Norris, JM
    Steenkiste, AR
    Aarons, JH
    Schmeltz, R
    Cruickshanks, KJ
    [J]. DIABETES RESEARCH AND CLINICAL PRACTICE, 1999, 43 (01) : 41 - 47
  • [5] FACTORS MODIFYING THE RISK OF IDDM IN OFFSPRING OF AN IDDM PARENT
    ELHASHIMY, M
    ANGELICO, MC
    MARTIN, BC
    KROLEWSKI, AS
    WARRAM, JH
    [J]. DIABETES, 1995, 44 (03) : 295 - 299
  • [6] Rising incidence of insulin dependent diabetes in children aged under 5 years in the Oxford region: time trend analysis
    Gardner, SG
    Bingley, PJ
    Sawtell, PA
    Weeks, S
    Gale, EAM
    Bell, RAF
    Dunger, DB
    Mukhtar, A
    OMalley, BP
    Silk, BR
    Smith, EH
    Scott, RDM
    Latham, PJ
    Lakhani, PK
    Paton, RC
    Ackland, FM
    Fox, CJ
    Griffin, NK
    Matthews, DR
    Neil, HAW
    Mann, NP
    Simpson, HCR
    Brown, RS
    Knight, AH
    Cowen, JM
    Pearce, JC
    Cheetham, CH
    Gallen, IW
    Sandler, L
    Westcott, T
    [J]. BRITISH MEDICAL JOURNAL, 1997, 315 (7110) : 713 - 717
  • [7] High familial risk and genetic susceptibility in early onset childhood diabetes
    Gillespie, KM
    Gale, EAM
    Bingley, PJ
    [J]. DIABETES, 2002, 51 (01) : 210 - 214
  • [8] Green A, 2000, LANCET, V355, P873
  • [9] Green A, 1998, DIABETOLOGIA, V41, P1151
  • [10] 1ST-TRIMESTER HEMOGLOBIN-A1 AND RISK FOR MAJOR MALFORMATION AND SPONTANEOUS-ABORTION IN DIABETIC PREGNANCY
    GREENE, MF
    HARE, JW
    CLOHERTY, JP
    BENACERRAF, BR
    SOELDNER, JS
    [J]. TERATOLOGY, 1989, 39 (03) : 225 - 231