T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't

被引：24

作者：

Dolganiuc, Angela ^{[1
]}

Szabo, Gyongyi ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Med, Div Gastroenterol, Worcester, MA 01605 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2008年 / 84卷 / 03期

关键词：

Tr1; Th3; CD8(+) Tregs; FoxP3; IL-10; TGF-beta; liver;

D O I：

10.1189/jlb.1107770

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The mechanism behind the apparent lack of effective antiviral immune response in patients with chronic hepatitis C virus (HCV) infection is poorly understood. Although multiple levels of abnormalities have been identified in innate and adaptive immunity, it remains unclear if any of the subpopulations of T cells with regulatory capacity (Tregs) contribute to the induction and maintenance of HCV persistence. In this review, we summarize the current knowledge about Tregs as they relate to HCV infection.

引用

页码：614 / 622

页数：9

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