Vaccines against human cytomegalovirus: Time to test

被引：28

作者：

Britt, WJ

机构：

[1] UNIV ALABAMA, DEPT PEDIAT, BIRMINGHAM, AL 35233 USA

[2] UNIV ALABAMA, DEPT MICROBIOL, BIRMINGHAM, AL 35233 USA

来源：

TRENDS IN MICROBIOLOGY | 1996年 / 4卷 / 01期

关键词：

D O I：

10.1016/0966-842X(96)81503-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Infections associated with human cytomegalovirus are an important cause of morbidity and mortality in immunocompromised individuals. Recent studies in humans and animal models have shown that some human cytomegalovirus proteins can induce protective immunity. The availability of recombinant viral proteins means that candidate subunit vaccines can now be tested in clinical trials.

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收藏

页码：34 / 38

页数：5

相关论文

共 47 条

[1] IMMUNITY INDUCED BY PRIMARY HUMAN CYTOMEGALOVIRUS-INFECTION PROTECTS AGAINST SECONDARY INFECTION AMONG WOMEN OF CHILDBEARING AGE [J].

ADLER, SP ;

STARR, SE ;

PLOTKIN, SA ;

HEMPFLING, SH ;

BUIS, J ;

MANNING, ML ;

BEST, AM .

JOURNAL OF INFECTIOUS DISEASES, 1995, 171 (01) :26-32

[2] CYTOMEGALO-VIRUS AND CHILD DAY-CARE - EVIDENCE FOR AN INCREASED INFECTION-RATE AMONG DAY-CARE WORKERS [J].

ADLER, SP .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (19) :1290-1296

[3]

ALFORD CA, 1990, VIROLOGY, P1981

[4] FINE SPECIFICITY OF CELLULAR IMMUNE-RESPONSES IN HUMANS TO HUMAN CYTOMEGALOVIRUS IMMEDIATE-EARLY 1-PROTEIN [J].

ALP, NJ ;

ALLPORT, TD ;

VANZANTEN, J ;

RODGERS, B ;

SISSONS, JGP ;

BORYSIEWICZ, LK .

JOURNAL OF VIROLOGY, 1991, 65 (09) :4812-4820

[5] COMPARATIVE-ANALYSIS OF 14 INDIVIDUAL HUMAN CYTOMEGALOVIRUS PROTEINS FOR HELPER T-CELL RESPONSE [J].

BENINGA, J ;

KROPFF, B ;

MACH, M .

JOURNAL OF GENERAL VIROLOGY, 1995, 76 :153-160

[6] ANTIVIRAL ANTIBODY-RESPONSES AND INTRAUTERINE TRANSMISSION AFTER PRIMARY MATERNAL CYTOMEGALOVIRUS-INFECTION [J].

BOPPANA, SB ;

BRITT, WJ .

JOURNAL OF INFECTIOUS DISEASES, 1995, 171 (05) :1115-1121

[7] VIRUS-SPECIFIC ANTIBODY-RESPONSES TO HUMAN CYTOMEGALOVIRUS (HCMV) IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE 1-INFECTED PERSONS WITH HCMV RETINITIS [J].

BOPPANA, SB ;

POLIS, MA ;

KRAMER, AA ;

BRITT, WJ ;

KOENIG, S .

JOURNAL OF INFECTIOUS DISEASES, 1995, 171 (01) :182-185

[8] FORMULATION OF AN IMMUNOGENIC HUMAN CYTOMEGALOVIRUS VACCINE - RESPONSES IN MICE [J].

BRITT, W ;

FAY, J ;

SEALS, J ;

KENSIL, C .

JOURNAL OF INFECTIOUS DISEASES, 1995, 171 (01) :18-25

[9] CELL-SURFACE EXPRESSION OF HUMAN CYTOMEGALOVIRUS (HCMV) GP55-116 (GB) - USE OF HCMV-RECOMBINANT VACCINIA VIRUS-INFECTED CELLS IN ANALYSIS OF THE HUMAN NEUTRALIZING ANTIBODY-RESPONSE [J].

BRITT, WJ ;

VUGLER, L ;

BUTFILOSKI, EJ ;

STEPHENS, EB .

JOURNAL OF VIROLOGY, 1990, 64 (03) :1079-1085

[10]

CHEE MS, 1990, CURR TOP MICROBIOL, V154, P125

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