Deletion of a cyclic AMP receptor protein homologue diminishes germination and affects morphological development of Streptomyces coelicolor

被引：56

作者：

Derouaux, A

Halici, S

Nothaft, H

Neutelings, T

Moutzourelis, G

Dusart, J

Titgemeyer, F

Rigali, S ^{[1
]}

机构：

[1] Univ Liege, Ctr Ingn Prot, Inst Chim, B-4000 Liege, Belgium

[2] Univ Erlangen Nurnberg, Lehrstuhl Mikrobiol, D-91058 Erlangen, Germany

来源：

JOURNAL OF BACTERIOLOGY | 2004年 / 186卷 / 06期

关键词：

D O I：

10.1128/JB.186.6.1893-1897.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Open reading frame SCO3571 of Streptomyces coelicolor encodes a protein of the cyclic AMP (cAMP) receptor protein (CRP) superfamily of regulatory proteins. A mutant revealed a dramatic defect in germination, followed by growth delay and earlier sporulation. This phenotype correlates with those of an adenylate cyclase (cya) mutant that cannot synthesize cAMP. This finding suggests that S. coelicolor may use a Cya-cAMP-CRP system to trigger complex physiological processes such as morphogenesis.

引用

页码：1893 / 1897

页数：5

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