Purmorphamine activates the Hedgehog pathway by targeting Smoothened

被引：308

作者：

Sinha, S ^{[1
]}

Chen, JK ^{[1
]}

机构：

[1] Stanford Univ, Dept Mol Pharmacol, Sch Med, Stanford, CA 94305 USA

来源：

NATURE CHEMICAL BIOLOGY | 2006年 / 2卷 / 01期

关键词：

D O I：

10.1038/nchembio753

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hedgehog (Hh) signaling is an important regulator of embryonic patterning, tissue regeneration, stem cell renewal and cancer growth. A purine derivative named purmorphamine was previously found to activate the Hh pathway and affect osteoblast differentiation through an unknown mechanism. We demonstrate here that purmorphamine directly targets Smoothened, a critical component of the Hh signaling pathway.

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页码：29 / 30

页数：2

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