Subtype and pathway specific responses to anticancer compounds in breast cancer

被引：359

作者：

Heiser, Laura M. ^{[1
]}

Sadanandam, Anguraj ^{[1
]}

Kuo, Wen-Lin ^{[1
]}

Benz, Stephen C. ^{[2
,3
]}

Goldstein, Theodore C. ^{[2
,3
]}

Ng, Sam ^{[2
,3
]}

Gibb, William J. ^{[1
]}

Wang, Nicholas J. ^{[1
]}

Ziyad, Safiyyah ^{[1
]}

Tong, Frances ^{[4
]}

Bayani, Nora ^{[1
]}

Hu, Zhi ^{[1
]}

Billig, Jessica I. ^{[1
]}

Dueregger, Andrea ^{[1
]}

Lewis, Sophia ^{[1
]}

Jakkula, Lakshmi ^{[1
]}

Korkola, James E. ^{[1
]}

Durinck, Steffen ^{[1
]}

Pepin, Francois ^{[1
]}

Guan, Yinghui ^{[1
]}

Purdom, Elizabeth ^{[4
]}

Neuvial, Pierre ^{[4
]}

Bengtsson, Henrik ^{[4
]}

Wood, Kenneth W. ^{[5
]}

Smith, Peter G. ^{[6
]}

Vassilev, Lyubomir T. ^{[7
]}

Hennessy, Bryan T. ^{[8
]}

Greshock, Joel ^{[9
]}

Bachman, Kurtis E. ^{[9
]}

Hardwicke, Mary Ann ^{[9
]}

Park, John W. ^{[10
]}

Marton, Laurence J. ^{[11
]}

Wolf, Denise M. ^{[1
]}

Collisson, Eric A. ^{[10
]}

Neve, Richard M. ^{[1
]}

Mills, Gordon B. ^{[8
]}

Speed, Terence P. ^{[4
,12
]}

Feiler, Heidi S. ^{[1
]}

Wooster, Richard F. ^{[9
]}

Haussler, David ^{[2
,3
,13
]}

Stuart, Joshua M. ^{[2
,3
]}

Gray, Joe W. ^{[1
]}

Spellman, Paul T. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Life Sci, Berkeley, CA 94720 USA

[2] Univ Calif Santa Cruz, Dept Biomol Engn, Santa Cruz, CA 94720 USA

[3] Univ Calif Santa Cruz, Ctr Biomol Sci & Engn, Santa Cruz, CA 94720 USA

[4] Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA

[5] Cytokinetics Inc, San Francisco, CA 94080 USA

[6] Millennium Pharmaceut Inc, Oncol, Cambridge, MA 02139 USA

[7] Hoffman La Roche, Nutley, NJ 07110 USA

[8] Univ Texas MD Anderson Canc Ctr, Dept Systems Biol, Houston, TX 77054 USA

[9] GlaxoSmithKline, Collegeville, PA 19426 USA

[10] Univ Calif San Francisco, Div Hematol Oncol, San Francisco, CA 94143 USA

[11] Progen Pharmaceut, Palo Alto, CA 94303 USA

[12] Walter & Eliza Hall Inst Med Res, Bioinformat Div, Melbourne, Vic 3052, Australia

[13] Univ Calif Santa Cruz, Howard Hughes Med Inst, Santa Cruz, CA 95064 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2012年 / 109卷 / 08期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

genomics; therapeutics; predictor; TAXOL-INDUCED APOPTOSIS; RAW COPY NUMBERS; CELL-LINES; KINASE INHIBITOR; FOXA1; EXPRESSION; BETA-CATENIN; RESISTANCE; CISPLATIN; ERBB2; CHEMOSENSITIVITY;

D O I：

10.1073/pnas.1018854108

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Breast cancers are comprised of molecularly distinct subtypes that may respond differently to pathway-targeted therapies now under development. Collections of breast cancer cell lines mirror many of the molecular subtypes and pathways found in tumors, suggesting that treatment of cell lines with candidate therapeutic compounds can guide identification of associations between molecular subtypes, pathways, and drug response. In a test of 77 therapeutic compounds, nearly all drugs showed differential responses across these cell lines, and approximately one third showed subtype-, pathway-, and/or genomic aberration-specific responses. These observations suggest mechanisms of response and resistance and may inform efforts to develop molecular assays that predict clinical response.

引用

页码：2724 / 2729

页数：6

共 37 条

[1]

Anonymous, 2010, NEW MED DATABASE PHR

[2] FOXA1 expression in breast cancer - Correlation with luminal subtype A and survival [J].

Badve, Sunil ;

Turbin, Dmitry ;

Thorat, Mangesh A. ;

Morimiya, Akira ;

Nielsen, Torsten O. ;

Perou, Charles M. ;

Dunn, Sandi ;

Huntsman, David G. ;

Nakshatri, Harikrishna .

CLINICAL CANCER RESEARCH, 2007, 13 (15) :4415-4421

[3] Novel anticancer targets: revisiting ERBB2 and discovering ERBB3 [J].

Baselga, Jose ;

Swain, Sandra M. .

NATURE REVIEWS CANCER, 2009, 9 (07) :463-475

[4] Estimation and assessment of raw copy numbers at the single locus level [J].

Bengtsson, H. ;

Irizarry, R. ;

Carvalho, B. ;

Speed, T. P. .

BIOINFORMATICS, 2008, 24 (06) :759-767

[5] A single-array preprocessing method for estimating full-resolution raw copy numbers from all Affymetrix genotyping arrays including GenomeWideSNP 5 & 6 [J].

Bengtsson, Henrik ;

Wirapati, Pratyaksha ;

Speed, Terence P. .

BIOINFORMATICS, 2009, 25 (17) :2149-2156

[6] Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma [J].

Beroukhim, Rameen ;

Getz, Gad ;

Nghiemphu, Leia ;

Barretina, Jordi ;

Hsueh, Teli ;

Linhart, David ;

Vivanco, Igor ;

Lee, Jeffrey C. ;

Huang, Julie H. ;

Alexander, Sethu ;

Du, Jinyan ;

Kau, Tweeny ;

Thomas, Roman K. ;

Shah, Kinial ;

Soto, Horacio ;

Perner, Sven ;

Prensner, John ;

Debiasi, Ralph M. ;

Demichelis, Francesca ;

Hatton, Charlie ;

Rubin, Mark A. ;

Garraway, Levi A. ;

Nelson, Stan F. ;

Liau, Linda ;

Mischel, Paul S. ;

Cloughesy, Tim F. ;

Meyerson, Matthew ;

Golub, Todd A. ;

Lander, Eric S. ;

Mellinghoff, Ingo K. ;

Sellers, William R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (50) :20007-20012

[7] Transcriptional switch by activating transcription factor 2-derived peptide sensitizes melanoma cells to apoptosis and inhibits their tumorigenicity [J].

Bhoumik, A ;

Jones, N ;

Ronai, Z .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (12) :4222-4227

[8] Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs [J].

Blagosklonny, MV .

LEUKEMIA, 2002, 16 (04) :455-462

[9] The triple negative paradox: Primary tumor chemosensitivity of breast cancer subtypes [J].

Carey, Lisa A. ;

Dees, E. Claire ;

Sawyer, Lynda ;

Gatti, Lisa ;

Moore, Dominic T. ;

Collichio, Frances ;

Ollila, David W. ;

Sartor, Carolyn I. ;

Graham, Mark L. ;

Perou, Charles M. .

CLINICAL CANCER RESEARCH, 2007, 13 (08) :2329-2334

[10] Forkhead-box A1 (FOXA1) expression in breast cancer and its prognostic significance [J].

Habashy, Hany Onsy ;

Powe, Desmond G. ;

Rakha, Emad A. ;

Ball, Graham ;

Paish, Claire ;

Gee, Julia ;

Nicholson, Robert I. ;

Ellis, Ian O. .

EUROPEAN JOURNAL OF CANCER, 2008, 44 (11) :1541-1551

← 1 2 3 4 →