Role of the Ubiquitin Proteasome System in the Heart

被引：113

作者：

Pagan, Julia ^{[2
,3
]}

Seto, Tiffany ^{[2
,3
]}

Pagano, Michele ^{[2
,3
]}

Cittadini, Antonio ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Translat Med Sci, Naples, Italy

[2] NYU, Sch Med, Dept Pathol, NYU Canc Inst, New York, NY USA

[3] Howard Hughes Med Inst, New York, NY USA

来源：

CIRCULATION RESEARCH | 2013年 / 112卷 / 07期

关键词：

heart failure; ischemia; myocardial remodeling; ventricular; proteasome endopeptidase complex; ubiquitin; ALPHA-B-CRYSTALLIN; NF-KAPPA-B; DEPENDENT CARDIAC-HYPERTROPHY; RING FINGER PROTEIN-1; 26S PROTEASOME; ISCHEMIA/REPERFUSION INJURY; MYOCARDIAL-INFARCTION; PROTEOLYTIC FUNCTION; CELL-PROLIFERATION; POTASSIUM CHANNEL;

D O I：

10.1161/CIRCRESAHA.112.300521

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Proper protein turnover is required for cardiac homeostasis and, accordingly, impaired proteasomal function appears to contribute to heart disease. Specific proteasomal degradation mechanisms underlying cardiovascular biology and disease have been identified, and such cellular pathways have been proposed to be targets of clinical relevance. This review summarizes the latest literature regarding the specific E3 ligases involved in heart biology, and the general ways that the proteasome regulates protein quality control in heart disease. The potential for therapeutic intervention in Ubiquitin Proteasome System function in heart disease is discussed. (Circ Res. 2013;112:1046-1058.)

引用

页码：1046 / 1058

页数：13

共 147 条

[1] Regulation of the cardiac voltage-gated Na+ channel (H1) by the ubiquitin-protein ligase Nedd4 [J].

Abriel, H ;

Kamynina, E ;

Horisberger, JD ;

Staub, O .

FEBS LETTERS, 2000, 466 (2-3) :377-380

[2] Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1 [J].

Albesa, Maxime ;

Grilo, Liliana Sintra ;

Gavillet, Bruno ;

Abriel, Hugues .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2011, 51 (01) :90-98

[3] Muscle ring finger protein-1 inhibits PKCε activation and prevents cardiomyocyte hypertrophy [J].

Arya, R ;

Kedar, V ;

Hwang, JR ;

McDonough, H ;

Li, HH ;

Taylor, J ;

Patterson, C .

JOURNAL OF CELL BIOLOGY, 2004, 167 (06) :1147-1159

[4] Ubipuitin-Proteasome System Impairment Caused by a Missense Cardiac Myosin-binding Protein C Mutation and Associated with Cardiac Dysfunction in Hypertrophic Cardiomyopathy [J].

Bahrudin, Udin ;

Morisaki, Hiroko ;

Morisaki, Takayuki ;

Ninomiya, Haruaki ;

Higaki, Katsumi ;

Nanba, Eiji ;

Igawa, Osamu ;

Takashima, Seiji ;

Mizutas, Einosuke ;

Miake, Junichiro ;

Yamamoto, Yasutaka ;

Shirayoshi, Yasuaki ;

Kitakaze, Masafumi ;

Carrier, Lucie ;

Hisatome, Ichiro .

JOURNAL OF MOLECULAR BIOLOGY, 2008, 384 (04) :896-907

[5] Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy [J].

Birks, Emma J. ;

Latif, Najma ;

Enesa, Karine ;

Folkvang, Tonje ;

Luong, Le Anh ;

Sarathchandra, Padmini ;

Khan, Mak ;

Ovaa, Huib ;

Terracciano, Cesare M. ;

Barton, Paul J. R. ;

Yacoub, Magdi H. ;

Evans, Paul C. .

CARDIOVASCULAR RESEARCH, 2008, 79 (03) :472-480

[6] Identification of ubiquitin ligases required for skeletal muscle atrophy [J].

Bodine, SC ;

Latres, E ;

Baumhueter, S ;

Lai, VKM ;

Nunez, L ;

Clarke, BA ;

Poueymirou, WT ;

Panaro, FJ ;

Na, EQ ;

Dharmarajan, K ;

Pan, ZQ ;

Valenzuela, DM ;

DeChiara, TM ;

Stitt, TN ;

Yancopoulos, GD ;

Glass, DJ .

SCIENCE, 2001, 294 (5547) :1704-1708

[7] Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases [J].

Bucciantini, M ;

Giannoni, E ;

Chiti, F ;

Baroni, F ;

Formigli, L ;

Zurdo, JS ;

Taddei, N ;

Ramponi, G ;

Dobson, CM ;

Stefani, M .

NATURE, 2002, 416 (6880) :507-511

[8] Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion [J].

Bulteau, AL ;

Lundberg, KC ;

Humphries, KM ;

Sadek, HA ;

Szweda, PA ;

Friguet, B ;

Szweda, LI .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (32) :30057-30063

[9] Ischemic preconditioning-induced cardioprotection is lost in mice with immunoproteasome subunit low molecular mass polypeptide-2 deficiency [J].

Cai, Zheqing P. ;

Shen, Zhenyun ;

Van Kaer, Luc ;

Becker, Lewis C. .

FASEB JOURNAL, 2008, 22 (12) :4248-4257

[10] Cardioprotective effects of a novel proteasome inhibitor following ischemia and reperfusion in the isolated perfused rat heart [J].

Campbell, B ;

Adams, J ;

Shin, YK ;

Lefer, AM .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1999, 31 (02) :467-476

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