Class 2 integron-associated antibiotic resistance in Shigella sonnei isolates in Dakar, Senegal

被引：22

作者：

Gassama-Sow, A

Diallo, MH

Boye, CS

Garin, B

Sire, JM

Sow, AI

Aïdara-Kane, A

机构：

[1] Inst Pasteur, Lab Bacteriol Expt, Dakar, Senegal

[2] CHU A Le Dantec, Lab Bacteriol Virol, Dakar, Senegal

[3] Inst Pasteur, Med Biol Lab, Dakar, Senegal

[4] CHN, Bacteriol Lab, Dakar, Senegal

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2006年 / 27卷 / 03期

关键词：

integron; Shigella sonnei; Senegal;

D O I：

10.1016/j.ijantimicag.2005.10.016

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Forty-three Shigella sonnei isolates from adult patients with diarrhoea in Dakar were analysed for the presence of integrons. Isolates were resistant to sulphamethoxazole, trimethoprim, tetracycline, streptomycin and spectinomycin. A high prevalence of class 2 integrons (93%) was found. These integrons showed three distinct structures: a class 2 integron, part of the Tn7 family and its derivatives, carrying four cassettes in the order dfrA1-sat-aadA1-orfX; a truncated class 2 integron, without orfX; and a third type ca. 4 kb in size. These class 2 integrons probably play a role in the spread of multiresistance in S. sonnei isolates. To our knowledge, this is the first description of class 2 integrons in S. sonnei isolated in sub-Saharan Africa. (c) 2005 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

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收藏

页码：267 / 270

页数：4

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