'Sialidase sensitivity' of rotaviruses revisited

被引:10
作者
Banda, Kalyan [1 ]
Kang, Gagandeep [1 ]
Varki, Ajit [2 ,3 ]
机构
[1] Christian Med Coll & Hosp, Dept Gastrointestinal Sci, Vellore 632004, Tamil Nadu, India
[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
关键词
ACID; STRAINS;
D O I
10.1038/nchembio0209-71
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Rotaviruses have been designated as 'sialidase sensitive' or 'sialidase insensitive', based on how their entry into cells is affected by treating cells with sialidases. A new study uses multiple methods, including saturation transfer difference NMR spectroscopy, to elucidate interesting interactions involving terminal and internal sialic acid moieties, concluding that 'sialidase insensitive' does not mean 'sialic acid independent'.
引用
收藏
页码:71 / 72
页数:3
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