Physiological migration of hematopoietic stem and progenitor Celts

被引：716

作者：

Wright, DE

Wagers, AJ

Gulati, AP

Johnson, FL

Weissman, IL ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA

[3] Stanford Univ, Palo Alto Vet Affairs Hlth Care Syst, Sch Med, Dept Med,Cardiovasc Med Div,Cardiol Sect 111C, Palo Alto, CA 94304 USA

来源：

SCIENCE | 2001年 / 294卷 / 5548期

关键词：

D O I：

10.1126/science.1064081

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hematopoietic stem cells (HSCs) reside predominantly in bone marrow, but low numbers of HSCs are also found in peripheral blood. We examined the fate of blood-borne HSCs using genetically marked parabiotic mice, which are surgically conjoined and share a common circulation. Parabionts rapidly established stable, functional cross engraftment of partner-derived HSCs and maintained partner-derived hematopoiesis after surgical separation. Determination of the residence time of injected blood-borne progenitor cells suggests that circulating HSCs/progenitors: are cleared quickly from the blood, These data demonstrate that HSCs rapidly and constitutively migrate through the blood and play a physiological role in, at least, the functional reengraftment of unconditioned bone marrow.

引用

页码：1933 / 1936

页数：4

共 23 条

[1] A clonogenic common myeloid progenitor that gives rise to all myeloid lineages [J].