Dopa decarboxylase: A model gene-enzyme system for studying development, behavior, and systematics

被引：57

作者：

Hodgetts, RB ^{[1
]}

O'Keefe, SL ^{[1
]}

机构：

[1] Univ Alberta, Dept Sci Biol, Edmonton, AB T6G 2E9, Canada

来源：

ANNUAL REVIEW OF ENTOMOLOGY | 2006年 / 51卷

关键词：

dopamine; serotonin; pigmentation; wound healing;

D O I：

10.1146/annurev.ento.51.110104.151143

中图分类号：

Q96 [昆虫学];

学科分类号：

摘要：

Throughout its long evolutionary history, the Dopa decarboxylase gene (Ddc) has acquired a variety of functions in insects. The enzyme (DDC) catalyzes the production of the neural transmitters dopamine and serotonin. Not surprisingly, evidence of the enzyme's involvement in the behavior of insects is beginning to accumulate. In addition, DDC plays a role in wound healing, parasite defense, pigmentation, and cuticle hardening. A high degree of sequence conservation has allowed comparisons of the Ddc-coding regions from various insects, facilitating a number of recent studies on insect systematics. This review outlines the diverse functions of Ddc and illustrates how studies of this model system address many questions on insect neurobiology, developmental biology, and systematics.

引用

页码：259 / 284

页数：28

共 149 条

[1] MOLECULAR ANALYSIS OF THE INITIATION OF INSECT METAMORPHOSIS - A COMPARATIVE-STUDY OF DROSOPHILA ECDYSTEROID-REGULATED TRANSCRIPTION [J].

ANDRES, AJ ;

FLETCHER, JC ;

KARIM, FD ;

THUMMEL, CS .

DEVELOPMENTAL BIOLOGY, 1993, 160 (02) :388-404

[2] SEQUENTIAL GENE ACTIVATION BY ECDYSONE IN POLYTENE CHROMOSOMES OF DROSOPHILA-MELANOGASTER .3. CONSEQUENCES OF ECDYSONE WITHDRAWAL [J].

ASHBURNER, M ;

RICHARDS, G .

DEVELOPMENTAL BIOLOGY, 1976, 54 (02) :241-255

[3]

ASHBURNER M, 1973, COLD SPRING HARB SYM, V38, P655

[4] The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway [J].

Baker, KD ;

Shewchuk, LM ;

Kozlova, T ;

Makishima, M ;

Hassell, A ;

Wisely, B ;

Caravella, JA ;

Lambert, MH ;

Reinking, JL ;

Krause, H ;

Thummel, CS ;

Willson, TM ;

Mangelsdorf, DJ .

CELL, 2003, 113 (06) :731-742

[5] Relationships between protein isoforms and genetic functions demonstrate functional redundancy at the Broad-Complex during Drosophila metamorphosis [J].

Bayer, CA ;

vonKalm, L ;

Fristrom, JW .

DEVELOPMENTAL BIOLOGY, 1997, 187 (02) :267-282

[6] HIGH-LEVELS OF INTRON-CONTAINING RNAS ARE ASSOCIATED WITH EXPRESSION OF THE DROSOPHILA DOPA DECARBOXYLASE GENE [J].

BEALL, CJ ;

HIRSH, J .

MOLECULAR AND CELLULAR BIOLOGY, 1984, 4 (09) :1669-1674

[7] REGULATION OF THE DROSOPHILA DOPA DECARBOXYLASE GENE IN NEURONAL AND GLIAL-CELLS [J].

BEALL, CJ ;

HIRSH, J .

GENES & DEVELOPMENT, 1987, 1 (05) :510-520

[8] Wasp parasitoid disruption of host development: Implications for new biologically based strategies for insect control [J].

Beckage, NE ;

Gelman, DB .

ANNUAL REVIEW OF ENTOMOLOGY, 2004, 49 :299-330

[9] L-dopa decarboxylase mRNA levels are correlated with the L-dopa decarboxylase protein profile during the development of the insect Ceratitis capitata [J].

Bossinakou, KS ;

Mantzouridis, TD ;

Fragoulis, EG .

INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1996, 26 (8-9) :859-865

[10]

BRAND AH, 1993, DEVELOPMENT, V118, P401

← 1 2 3 4 5 6 7 8 9 10 →