Defective calcium transport in vitiliginous melanocytes

被引：65

作者：

SchallreuterWood, KU ^{[1
]}

Pittelkow, MR ^{[1
]}

Swanson, NN ^{[1
]}

机构：

[1] MAYO CLIN, DEPT DERMATOL, ROCHESTER, MN USA

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 1996年 / 288卷 / 01期

关键词：

calcium transport; melanocytes; vitiligo; 6-biopterin/6BH(4); redox;

D O I：

10.1007/BF02505036

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Melanocytes were successfully established from involved and uninvolved skin of a patient with acute acrofacial vitiligo. Cells from involved epidermis showed a fivefold decrease in the rate of radiolabelled Ca-45 uptake compared with uninvolved and control cells. These results are similar to previous findings in keratinocytes from involved skin in patients with vitiligo. Since 6-biopterin is cytotoxic to melanocytes and calcium controls the redox status of the 6-biopterin/(6R)5, 6, 7, 8-tetrahydrobiopterin equilibrium via the thioredoxin reductase/thioredoxin system, these results underline the importance of this electron transfer system for both melanocyte function and survival.

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页码：11 / 13

页数：3

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