Proteome imaging: A closer look at life's organization

被引：18

作者：

Heeren, RMA ^{[1
]}

机构：

[1] FOM, Inst Atom & Mol Phys, NL-1098 SJ Amsterdam, Netherlands

来源：

PROTEOMICS | 2005年 / 5卷 / 17期

关键词：

proteome imaging; review;

D O I：

10.1002/pmic.200500406

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Imaging the proteome is a term that is used in many different contexts. The term implies that the entire cohort of proteins and their modifications are visualized. This unfortunately is not the case. In this mini-review, a concise overview is provided on different imaging technologies that are currently used to investigate the structure, function and dynamics of proteins and their organization. These techniques have been selected for review based on the unique insights they provide in subsets of the proteome. These techniques have been illustrated with practical examples of their merits. Mass spectrometry-based imaging technologies are playing a key role in proteome research and have been reviewed in more detail. They hold the promise of detailed molecular insight in the spatial organization of living system.

引用

页码：4316 / 4326

页数：11

共 76 条

[1] Organic SIMS: the influence of time on the ion yield enhancement by silver and gold deposition [J].

Adriaensen, L ;

Vangaever, F ;

Gijbels, R .

APPLIED SURFACE SCIENCE, 2004, 231 :256-260

[2] Cryo-negative staining [J].

Adrian, M ;

Dubochet, J ;

Fuller, SD ;

Harris, JR .

MICRON, 1998, 29 (2-3) :145-160

[3] Mass spectrometry-based proteomics [J].

Aebersold, R ;

Mann, M .

NATURE, 2003, 422 (6928) :198-207

[4] Direct molecular Imaging of Lymnaea stagnalis nervous tissue at subcellular spatial resolution by mass spectrometry [J].

Altelaar, AFM ;

van Minnen, J ;

Jiménez, CR ;

Heeren, RMA ;

Piersma, SR .

ANALYTICAL CHEMISTRY, 2005, 77 (03) :735-741

[5] ADSORPTION AND SURFACE REACTIVITY OF METALS BY SECONDARY ION MASS-SPECTROMETRY .1. ADSORPTION OF CARBON-MONOXIDE ON NICKEL AND COPPER [J].

BARBER, M ;

VICKERMAN, JC ;

WOLSTENHOLME, J .

JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS I, 1976, 72 :40-50

[6] Quantitative protein profiling using antibody arrays [J].

Barry, R ;

Soloviev, M .

PROTEOMICS, 2004, 4 (12) :3717-3726

[7] Observing proteins in their natural habitat: the living cell [J].

Bastiaens, PIH ;

Pepperkok, R .

TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (12) :631-637

[8] TOF-SIMS characterization and imaging of controlled-release drug delivery systems [J].

Belu, AM ;

Davies, MC ;

Newton, JM ;

Patel, N .

ANALYTICAL CHEMISTRY, 2000, 72 (22) :5625-5638

[9]

Berkenkamp S, 1997, RAPID COMMUN MASS SP, V11, P1399

[10] A molecular scanner to automate proteomic research and to display proteome images [J].

Binz, PA ;

Müller, M ;

Walther, D ;

Bienvenut, WV ;

Gras, R ;

Hoogland, C ;

Bouchet, G ;

Gasteiger, E ;

Fabbretti, R ;

Gay, S ;

Palagi, P ;

Wilkins, MR ;

Rouge, V ;

Tonella, L ;

Paesano, S ;

Rossellat, G ;

Karmime, A ;

Bairoch, A ;

Sanchez, JC ;

Appel, RD ;

Hochstrasser, DF .

ANALYTICAL CHEMISTRY, 1999, 71 (21) :4981-4988

← 1 2 3 4 5 6 7 8 →