Synthesis, structure and cytotoxicity of organoammonium selenites

被引：22

作者：

Lukevics, E ^{[1
]}

Arsenyan, P ^{[1
]}

Shestakova, I ^{[1
]}

Domracheva, I ^{[1
]}

Kanepe, I ^{[1
]}

Belyakov, S ^{[1
]}

Popelis, J ^{[1
]}

Pudova, O ^{[1
]}

机构：

[1] Latvian Inst Organ Synthesis, LV-1006 Riga, Latvia

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2002年 / 16卷 / 04期

关键词：

antitumor activity; cytotoxicity; morphology; selenium; X-ray;

D O I：

10.1002/aoc.276

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

New selenites of different organic bases have been prepared by the reaction of selenium dioxide with aliphatic and heterocyclic amines in an aqueous medium. Their structure was confirmed by H-1, C-13 and Se-77 NMR data and, in the case of triethanolammonium hydroselenite [HN+(CH2CH2OH)(3) HSeO3], by X-ray analysis. Most of these selenites have an expressed cytotoxic activity on the MG-22A (mouse hepatoma), HT-1080 (human fibrosarcoma), B16 (mouse melanoma), and Neuro 2A (mouse neuroblastoma) cell lines. The substances studied were also active in vivo against sarcoma S-180. Copyright (C) 2002 John Wiley Sons, Ltd.

引用

页码：228 / 234

页数：7

共 32 条

[1] Selenium and cancer: Some nutritional aspects [J].