Production of Pharmaceutical Proteins in Solanaceae Food Crops

被引：25

作者：

Rigano, Maria Manuela ^{[1
]}

De Guzman, Giorgio ^{[2
]}

Walmsley, Amanda M. ^{[2
]}

Frusciante, Luigi ^{[1
]}

Barone, Amalia ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Agr Sci, I-80055 Naples, Italy

[2] Monash Univ, Sch Biol Sci, Clayton, Vic 3800, Australia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 02期

关键词：

plant-made vaccines; Solanaceae; transgenic plant; food crop; TOXIN-B-SUBUNIT; RECOMBINANT PROTEINS; ORAL IMMUNOGENICITY; HEPATITIS-B; GENETIC-TRANSFORMATION; SURFACE-ANTIGEN; PLANT-MADE; CAROTENOID BIOSYNTHESIS; TRANSGENE EXPRESSION; SOLANUM-LYCOPERSICON;

D O I：

10.3390/ijms14022753

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The benefits of increased safety and cost-effectiveness make vegetable crops appropriate systems for the production and delivery of pharmaceutical proteins. In particular, Solanaceae edible crops could be inexpensive biofactories for oral vaccines and other pharmaceutical proteins that can be ingested as minimally processed extracts or as partially purified products. The field of crop plant biotechnology is advancing rapidly due to novel developments in genetic and genomic tools being made available today for the scientific community. In this review, we briefly summarize data now available regarding genomic resources for the Solanaceae family. In addition, we describe novel strategies developed for the expression of foreign proteins in vegetable crops and the utilization of these techniques to manufacture pharmaceutical proteins.

引用

页码：2753 / 2773

页数：21

共 112 条

[1] Expression of modified gene encoding functional human α-1-antitrypsin protein in transgenic tomato plants [J].

Agarwal, Saurabh ;

Singh, Rahul ;

Sanyal, Indraneel ;

Amla, D. V. .

TRANSGENIC RESEARCH, 2008, 17 (05) :881-896

[2] Plant-made subunit vaccine against pneumonic and bubonic plague is orally immunogenic in mice [J].

Alvarez, ML ;

Pinyerd, HL ;

Crisantes, JD ;

Rigano, MM ;

Pinkhasov, J ;

Walmsley, AM ;

Mason, HS ;

Cardineau, GA .

VACCINE, 2006, 24 (14) :2477-2490

[3] Production of recombinant anthrax toxin receptor (ATR/CMG2) fused with human Fc in planta [J].

Andrianov, V. ;

Brodzik, R. ;

Spitsin, S. ;

Bandurska, K. ;

McManus, H. ;

Koprowski, H. ;

Golovkin, M. .

PROTEIN EXPRESSION AND PURIFICATION, 2010, 70 (02) :158-162

[4] Enhancement of Carotenoid Biosynthesis in Transplastomic Tomatoes by Induced Lycopene-to-Provitamin A Conversion [J].

Apel, Wiebke ;

Bock, Ralph .

PLANT PHYSIOLOGY, 2009, 151 (01) :59-66

[5] Expression of the rabies virus nucleoprotein in plants at high-levels and evaluation of immune responses in mice [J].

Arango, Irene Perea ;

Rubio, Elizabeth Loza ;

Anaya, Edith Rojas ;

Flores, Teresa Olivera ;

de la Vara, Luis Gonzalez ;

Lim, Miguel Angel Gomez .

PLANT CELL REPORTS, 2008, 27 (04) :677-685

[6] Recombinant aprotinin produced transgenic corn seed: Extraction and purification studies [J].

Azzoni, AR ;

Kusnadi, AR ;

Miranda, EA ;

Nikolov, ZL .

BIOTECHNOLOGY AND BIOENGINEERING, 2002, 80 (03) :268-276

[7] Unintended molecular interactions in transgenic plants expressing clinically useful proteins: The case of bovine aprotinin traveling the potato leaf cell secretory pathway [J].

Badri, M. Amine ;

Rivard, Daniel ;

Coenen, Karine ;

Michaud, Dominique .

PROTEOMICS, 2009, 9 (03) :746-756

[8] A SELDI-TOF MS procedure for the detection, quantitation, and preliminary characterization of low-molecular-weight recombinant proteins expressed in transgenic plants [J].

Badri, M. Amine ;

Rivard, Daniel ;

Coenen, Karine ;

Vaillancourt, Louis-Philippe ;

Goulet, Charles ;

Michaud, Dominique .

PROTEOMICS, 2009, 9 (02) :233-241

[9] RNA-seq discovery, functional characterization, and comparison of sesquiterpene synthases from Solanum lycopersicum and Solanum habrochaites trichomes [J].

Bleeker, Petra M. ;

Spyropoulou, Eleni A. ;

Diergaarde, Paul J. ;

Volpin, Hanne ;

De Both, Michiel T. J. ;

Zerbe, Philipp ;

Bohlmann, Joerg ;

Falara, Vasiliki ;

Matsuba, Yuki ;

Pichersky, Eran ;

Haring, Michel A. ;

Schuurink, Robert C. .

PLANT MOLECULAR BIOLOGY, 2011, 77 (4-5) :323-336

[10] Solar-powered factories for new vaccines and antibiotics [J].

Bock, Ralph ;

Warzecha, Heribert .

TRENDS IN BIOTECHNOLOGY, 2010, 28 (05) :246-252

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