Rosiglitazone Reduces Angiotensin II and Advanced Glycation End Product-dependent Sustained Nuclear Factor-κB Activation in Cultured Human Proximal Tubular Epithelial Cells

被引：35

作者：

Morcos, M. ^{[1
,7
]}

Schlotterer, A. ^{[1
,7
]}

Sayed, A. A. R. ^{[1
,7
]}

Kukudov, G. ^{[1
,7
]}

Oikomonou, D. ^{[1
,7
]}

Ibrahim, Y. ^{[1
,7
]}

Pfisterer, F. ^{[1
,7
]}

Schneider, J. ^{[1
,2
,7
]}

Bozorgmehr, F. ^{[1
,7
]}

Rudofsky, G., Jr. ^{[1
,7
]}

Schwenger, V. ^{[1
,7
]}

Kientsch-Engels, R. ^{[3
]}

Hamann, A. ^{[1
,6
,7
]}

Zeier, M. ^{[1
,7
]}

Dugi, K. ^{[4
]}

Yard, B. ^{[5
]}

Humpert, P. M. ^{[1
,7
]}

van der Woude, F. ^{[5
]}

Nawroth, P. P. ^{[1
,7
]}

Bierhaus, A. ^{[1
,7
]}

机构：

[1] Heidelberg Univ, Dept Internal Med Endocrinol Metab & Clin Chem 1, D-69120 Heidelberg, Germany

[2] Univ Saarland, Teaching Hosp Merzig Saar, Saarland, Germany

[3] Roche Diagnost, Penzberg, Germany

[4] Boehringer Ingelheim Corp, Ingelheim, Germany

[5] Univ Mannheim, Med Clin 5, D-6800 Mannheim 1, Germany

[6] Diabet Clin Bad Nauheim, Bad Nauheim, Germany

[7] Heidelberg Univ, Renal Dept, D-69120 Heidelberg, Germany

来源：

HORMONE AND METABOLIC RESEARCH | 2008年 / 40卷 / 11期

关键词：

cellular activation; late diabetic complication; diabetic nephropathy; thiazolidindiones; reactive oxygen species;

D O I：

10.1055/s-0028-1082039

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tubular damage is a major feature in the development of diabetic nephropathy. This study investigates the effects of the thiazolidindione rosiglitazone on angiotensin II and advanced glycation end product-induced tubular activation in human proximal tubular epithelial cells in vitro. Angiotensin II and advanced glycation end products, both induced a dose-dependent sustained activation of the redox-sensitive transcription factor, Nuclear Factor kappa B (NF-kappa B). Nuclear translocation of NF-kappa B was evident already after one hour and persistent for more than four days. Co-incubation of proximal tubular epithelial cells with rosiglitazone significantly reduced angiotensin II and advanced glycation end product-mediated generation of reactive oxygen species, angiotensin II-dependent advanced glycation end product formation, NF-kappa B activation, and NF-kappa B-dependent pro inflammatory gene expression. Most importantly, rosiglitazone effects on NF kappa B activation were maximal at later time points, indicating that rosiglitazone treatment confers long lasting renoprotective effects.

引用

页码：752 / 759

页数：8

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