Antioxidant activity and protective effect on DNA cleavage of resveratrol

被引:31
作者
Acquaviva, R [1 ]
Russo, A [1 ]
Campisi, A [1 ]
Sorrenti, V [1 ]
Di Giacomo, C [1 ]
Barcellona, ML [1 ]
Avitabile, M [1 ]
Vanella, A [1 ]
机构
[1] Univ Catania, Dept Biochem Med Chem & Mol Biol, I-95125 Catania, Italy
关键词
antioxidant; DNA cleavage; lipid oxidation; resveratrol; xanthine oxidase;
D O I
10.1111/j.1365-2621.2002.tb11373.x
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
The major natural polyphenols of wine are flavonoids. Red wine also contains a natural phytoalexin called resveratrol which recently has been the subject of conflicting reports regarding its protective role against cardiovascular diseases. We have investigated the free radical scavenging capacity of resveratrol, its effects on xanthine oxidase (XO) activity, spontaneous membrane lipid oxidation, and DNA cleavage. Resveratrol showed a dose-dependent free radical scavenging activity, significant inhibition of XO activity, an anti-lipoperoxidative capacity, and a protective effect on DNA cleavage. The antioxidant capacity of resveratrol is ascribed to the concomitant activities of scavenging free radicals, metal chelating, and inhibition of some enzymes involved in free radical generation.
引用
收藏
页码:137 / 141
页数:5
相关论文
共 42 条
  • [1] OXIDANTS, ANTIOXIDANTS, AND THE DEGENERATIVE DISEASES OF AGING
    AMES, BN
    SHIGENAGA, MK
    HAGEN, TM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) : 7915 - 7922
  • [2] Interrelationship between cellular calcium homeostasis and free radical generation in myocardial reperfusion injury
    Bagchi, D
    Wetscher, GJ
    Bagchi, M
    Hinder, PR
    Perdikis, G
    Stohs, SJ
    Hinder, RA
    Das, DK
    [J]. CHEMICO-BIOLOGICAL INTERACTIONS, 1997, 104 (2-3) : 65 - 85
  • [3] Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins
    Belguendouz, L
    Fremont, L
    Linard, A
    [J]. BIOCHEMICAL PHARMACOLOGY, 1997, 53 (09) : 1347 - 1355
  • [4] Bertelli AAE, 1996, DRUG EXP CLIN RES, V22, P61
  • [5] Bonina F., 1998, International Journal of Cosmetic Science, V20, P331
  • [6] Effects of trans-resveratrol on copper-dependent hydroxyl-radical formation and DNA damage:: Evidence for hydroxyl-radical scavenging and a novel, glutathione-sparing mechanism of action
    Burkitt, MJ
    Duncan, J
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2000, 381 (02) : 253 - 263
  • [7] CHEMISTRY AND BIOCHEMISTRY OF 4-HYDROXYNONENAL, MALONALDEHYDE AND RELATED ALDEHYDES
    ESTERBAUER, H
    SCHAUR, RJ
    ZOLLNER, H
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 1991, 11 (01) : 81 - 128
  • [8] FEIG DI, 1994, CANCER RES, V54, pS1890
  • [9] Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids
    Frémont, L
    Belguendouz, L
    Delpal, S
    [J]. LIFE SCIENCES, 1999, 64 (26) : 2511 - 2521
  • [10] The potential role of iron chelators in the treatment of Parkinson's disease and related neurological disorders
    Gassen, M
    Youdim, MBH
    [J]. PHARMACOLOGY & TOXICOLOGY, 1997, 80 (04): : 159 - 166