N-acetylcysteine for preventing pump-induced oxidoinflammatory response during cardiopulmonary bypass

被引:54
作者
Sucu, N
Cinel, I
Unlu, A
Aytacoglu, B
Tamer, L
Kocak, Z
Karaca, K
Gul, A
Dikmengil, M
Atik, U
Oral, U
机构
[1] Mersin Univ, Sch Med, Dept Cardiovasc Surg, TR-33079 Mersin, Turkey
[2] Mersin Univ, Sch Med, Dept Anesthesiol & Reanimat, TR-33079 Mersin, Turkey
[3] Mersin Univ, Sch Med, Dept Biochem, TR-33079 Mersin, Turkey
关键词
N-acetylcysteine; cardiopulmonary bypass; interleukin-6; lipid peroxidation; myeloperoxidase; acute phase reactant;
D O I
10.1007/s00595-003-2699-8
中图分类号
R61 [外科手术学];
学科分类号
摘要
Purpose. To investigate the effect of N-acetylcysteine on preventing pump-induced oxidoinflammatory response during cardiopulmonary bypass (CPB). Methods. Forty patients undergoing coronary artery bypass grafting (CABG) were randomly divided into a study group (n = 20), given 50 mg kg(-1) N-acetylcysteine intravenously for 3 days, and a control group (n = 20) given saline. Serum samples were collected for measurement of myeloperoxidase (MPO), malondialdehyde (MDA), interleukin-6, alpha(1)-acid glycoprotein (AAGP), and C-reactive protein (CRP) during surgery and postoperatively. Results. The MPO and MDA values showed a similar pattern during and after CPB in the study group, with significantly less variance than in the control group. Interleukin-6 showed similar patterns in the two groups, but the data from 30 min after the start of CPB and from 6 h post-CPB were significantly different. The AAGP and CRP values were both elevated during CPB in the two groups without a significant difference, but 6 and 24 h post-CPB, the values were significantly higher in the control group than in the study group. Conclusions. N-Acetylcysteine decreased pump-induced oxidoinflammatory response during CPB, suggesting that it could be a novel therapy for assisting in the prevention of CBP-induced oxidoinflammatory damage.
引用
收藏
页码:237 / 242
页数:6
相关论文
共 29 条
[1]  
[Anonymous], METHODS ENZYMOLOGY
[2]   THE ANTIOXIDANT ACTION OF N-ACETYLCYSTEINE - ITS REACTION WITH HYDROGEN-PEROXIDE, HYDROXYL RADICAL, SUPEROXIDE, AND HYPOCHLOROUS ACID [J].
ARUOMA, OI ;
HALLIWELL, B ;
HOEY, BM ;
BUTLER, J .
FREE RADICAL BIOLOGY AND MEDICINE, 1989, 6 (06) :593-597
[3]   Inflammatory response after coronary revascularization with or without cardiopulmonary bypass [J].
Ascione, R ;
Lloyd, CT ;
Underwood, MJ ;
Lotto, AA ;
Pitsis, AA ;
Angelini, GD .
ANNALS OF THORACIC SURGERY, 2000, 69 (04) :1198-1204
[4]   Effects of cardiopulmonary bypass on leukocyte and endothelial adhesion molecules [J].
Asimakopoulos, G ;
Taylor, KM .
ANNALS OF THORACIC SURGERY, 1998, 66 (06) :2135-2144
[5]  
BISHOP ML, 1996, FREE RADICALS CLIN C, P765
[6]   RETRACTED: CIRCULATING ADHESION MOLECULES IN CARDIAC OPERATIONS - INFLUENCE OF HIGH-DOSE APROTININ (Retracted article. See vol. 111, 2021) [J].
BOLDT, J ;
OSMER, C ;
SCHINDLER, E ;
LINKE, LC ;
STERTMANN, WA ;
HEMPELMANN, G .
ANNALS OF THORACIC SURGERY, 1995, 59 (01) :100-105
[7]   RETRACTED: Are circulating adhesion molecules specifically changed in cardiac surgical patients? (Retracted article. See vol. 111, 2021) [J].
Boldt, J ;
Kumle, B ;
Papsdorf, M ;
Hempelmann, G .
ANNALS OF THORACIC SURGERY, 1998, 65 (03) :608-614
[8]  
Carden DL, 2000, J PATHOL, V190, P255, DOI 10.1002/(SICI)1096-9896(200002)190:3<255::AID-PATH526>3.0.CO
[9]  
2-6
[10]   Protective effects of n-acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat [J].
Cuzzocrea, S ;
Mazzon, E ;
Dugo, L ;
Serraino, I ;
Ciccolo, A ;
Centorrino, T ;
De Sarro, A ;
Caputi, AP .
FASEB JOURNAL, 2001, 15 (07) :1187-1200