Oxidative resolution of 2-cyclopentenols by the asymmetric hydrogen transfer protocol

被引：26

作者：

Iura, Y ^{[1
]}

Sugahara, T ^{[1
]}

Ogasawara, K ^{[1
]}

机构：

[1] Tohoku Univ, Inst Pharmaceut, Aobayama, Sendai 9808578, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 31期

关键词：

catalysis; enantioselection; oxidation; ruthenium and compounds; transfer reactions;

D O I：

10.1016/S0040-4039(99)01087-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Ru-II-chiral amine complex has accomplished oxidative resolution of the 2-cyclopentene-1-ols having a bicyclo[2.2.1]heptene background to afford the cyclopentenones and the cyclopentenols both in good to excellent optical and chemical yields by an asymmetric hydrogen transfer reaction. The hydrogen transfer occurred selectively at the allylic methine hydrogen even though allylic methylene hydrogens are present at the same relative position. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：5735 / 5738

页数：4

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