Mitogen-activated protein kinases in hemostasis and thrombosis

被引：136

作者：

Adam, F. ^{[1
]}

Kauskot, A. ^{[1
]}

Rosa, J. -P. ^{[1
]}

Bryckaert, M. ^{[1
]}

机构：

[1] Hop Lariboisiere, INSERM, Ctr Rech Cardiovasc, Lariboisier U689 E4, F-75010 Paris, France

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2008年 / 6卷 / 12期

关键词：

MAP kinases; platelets; thrombosis;

D O I：

10.1111/j.1538-7836.2008.03169.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The mitogen-activated protein (MAP) kinases ERK2, p38 and JNK1 are present in platelets and are activated by various stimuli, such as thrombin, collagen, von Willebrand factor (VWF) and ADP. Until recently, MAP kinases were only studied in the conventional model of agonist-induced platelet aggregation mediated by fibrinogen and integrin alpha(IIb)beta(3). However, this approach is likely to be too limited for a physiological understanding of platelet MAP kinases and their signaling pathways. Recent studies with varying blood-flow conditions and animal models of thrombosis have provided deeper insight into the role of MAP kinases in thrombus formation and the dependence of these kinases on shear conditions. This review summarizes and discusses the physiological functions of these kinases in hemostasis and thrombosis as revealed by various technical approaches.

引用

页码：2007 / 2016

页数：10

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