Evidence for linkage between essential hypertension and a putative locus on human chromosome 17

被引：86

作者：

Baima, J

Nicolaou, M

Schwartz, F

DeStefano, AL

Manolis, A

Gavras, I

Laffer, C

Elijovich, F

Farrer, L

Baldwin, CT

Gavras, H

机构：

[1] Boston Univ, Sch Med, Hypertens Sect, Dept Med, Boston, MA 02118 USA

[2] Boston Univ, Sch Med, Genet Program, Boston, MA 02118 USA

[3] Boston Univ, Sch Med, Ctr Human Genet, Boston, MA 02118 USA

[4] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

[5] Boston Univ, Sch Med, Dept Pediat, Boston, MA 02118 USA

[6] Univ Texas, Med Branch, Dept Internal Med, Hypertens Sect, Galveston, TX 77550 USA

[7] Boston Univ, Sch Med, Dept Epidemiol & Biostat, Boston, MA 02118 USA

来源：

HYPERTENSION | 1999年 / 34卷 / 01期

关键词：

hypertension; essential; linkage; chromosome; 17; blood pressure; obesity;

D O I：

10.1161/01.HYP.34.1.4

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Several clinical and animal studies indicate that essential hypertension is inherited as a multifactorial trait with a significant genetic and environmental component. In the stroke-prone spontaneously hypertensive rat model, investigators have found evidence for linkage to blood pressure regulatory genes (quantitative trait loci) on rat chromosomes 2, 10, and X. In 1 human study of French and UK sib pairs, evidence for linkage has been reported to human chromosome 17q, the syntenic region of the rat chromosome 10 quantitative trait loci (QTL). Our study confirms this linkage (P=0.0005) and refines the location of the blood pressure QTL.

引用

页码：4 / 7

页数：4

共 24 条

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