The SAR of UK-78,282: A novel blocker of human T cell Kv1.3 potassium channels

被引：22

作者：

Burgess, LE

Koch, K

Cooper, K

Biggers, MS

Ramchandani, M

Smitrovich, JH

Gilbert, EJ

Bruns, MJ

Mather, RJ

Donovan, CB

Hanson, DC

机构：

[1] PFIZER INC,DIV CENT RES,DEPT MED CHEM,GROTON,CT 06340

[2] PFIZER INC,DIV CENT RES,DEPT IMMUNOL,GROTON,CT 06340

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(97)00163-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

UK-78,282 was identified in a human T cell Rb-86 efflux high-throughput screen of our compound libraries. This compound was found to be a potent and selective blacker of human T cell voltage-gated K+ channels and to inhibit T cell activation. The SAR around UK-78,282 and a general pharmacophore hypothesis are presented in this communication. (C) 1997 Elsevier Science Ltd.

引用

页码：1047 / 1052

页数：6

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