One Year Follow-Up of Children and Adolescents With Chronic Immune Thrombocytopenic Purpura (ITP) Treated With Rituximab

被引：41

作者：

Mueller, Brigitta U. ^{[2
,3
]}

Bennett, Carolyn M. ^{[1
,4
]}

Feldman, Henry A. ^{[4
,5
]}

Bussel, James B. ^{[6
]}

Abshire, Thomas C. ^{[7
]}

Moore, Theodore B. ^{[8
]}

Sawaf, Hadi ^{[9
]}

Loh, Mignon L. ^{[10
]}

Rogers, Zora R. ^{[11
]}

Glader, Bertil E. ^{[12
]}

McCarthy, Maggie C. ^{[4
,5
]}

Mahoney, Donald H. ^{[2
,3
]}

Olson, Thomas A. ^{[7
]}

Feig, Stephen A. ^{[8
]}

Lorenzana, Adonis N. ^{[9
]}

Mentzer, William C. ^{[10
]}

Buchanan, George R. ^{[11
]}

Neufeld, Ellis J. ^{[1
]}

机构：

[1] Childrens Hosp, Div Hematol Oncol, Dana Farber Canc Inst, Boston, MA 02115 USA

[2] Baylor Coll Med, Hematol Serv, Houston, TX 77030 USA

[3] Baylor Coll Med, Texas Childrens Canc Ctr, Houston, TX 77030 USA

[4] Harvard Univ, Sch Med, Boston, MA USA

[5] Childrens Hosp, Clin Res Program, Boston, MA 02115 USA

[6] Cornell Univ, Dept Pediat, Weill Med Coll, New York, NY 10021 USA

[7] Emory Univ, Sch Med, Atlanta, GA USA

[8] Univ Calif Los Angeles, Mattel Childrens Hosp, Los Angeles, CA USA

[9] St Johns Hosp, Van Eslander Canc Ctr, Detroit, MI USA

[10] Univ Calif San Francisco, San Francisco, CA 94143 USA

[11] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA

[12] Stanford Univ, Stanford, CA 94305 USA

来源：

PEDIATRIC BLOOD & CANCER | 2009年 / 52卷 / 02期

关键词：

clinical trial; immune thrombocytopenia; rituximab; ANTI-CD20; MONOCLONAL-ANTIBODY; INTRAVENOUS GAMMA-GLOBULIN; CHILDHOOD; EFFICACY; ADULTS;

D O I：

10.1002/pbc.21757

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background. We previously showed in a prospective Study that rituximab appears to be effective in some children and adolescents with severe chronic immune thrombocytopenia. Eleven of 36 patients achieved and maintained platelet counts Over 50,000/mm(3) within the first 12 weeks. These patients were followed for the next year. Methods. Platelet Count,; were monitored monthly and all subsequent bleeding manifestations and need for further treatment was noted. Results. Eight of the 11 initial responders maintained a platelet count over 150,000/mm(3) Without further treatment intervention. Three patients had a late relapse. One initial non-responder achieved a remission after 16 weeks, and two additional patients maintained platelet counts around 50,000/mm(3) without the need for further intervention. Conclusions. Rituximab resulted in sustained efficacy with platelet Counts of 50,000/mm(3) or higher in 11 of 36 patients (31%). Pediatr Blood Cancer 2009;52:259-262. (C) 2008 Wiley-Liss, Inc.

引用

页码：259 / 262

页数：4

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