Eosinophilia: secondary, clonal and idiopathic

被引:205
作者
Tefferi, A
Patnaik, MM
Pardanani, A
机构
[1] Mayo Clin & Mayo Fdn, Coll Med, Dept Internal Med, Div Hematol, Rochester, MN 55905 USA
[2] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA
关键词
hypereosinophilic syndrome; FIP1L1-PDGFRA; imatinib mesylate; diagnosis; treatment;
D O I
10.1111/j.1365-2141.2006.06038.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Blood eosinophilia signifies either a cytokine-mediated reactive phenomenon (secondary) or an integral phenotype of an underlying haematological neoplasm (primary). Secondary eosinophilia is usually associated with parasitosis in Third World countries and allergic conditions in the West. Primary eosinophilia is operationally classified as being clonal or idiopathic, depending on the respective presence or absence of a molecular, cytogenetic or histological evidence for a myeloid malignancy. The current communication features a comprehensive clinical summary of both secondary and primary eosinophilic disorders with emphasis on recent developments in molecular pathogenesis and treatment.
引用
收藏
页码:468 / 492
页数:25
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