C-type lectins in immunity and homeostasis

被引：590

作者：

Brown, Gordon D. ^{[1
]}

Willment, Janet A. ^{[1
]}

Whitehead, Lauren ^{[1
]}

机构：

[1] Univ Aberdeen, Med Res Council Ctr Med Mycol, Aberdeen Fungal Grp, Inst Med Sci, Foresterhill, Aberdeen, Scotland

来源：

NATURE REVIEWS IMMUNOLOGY | 2018年 / 18卷 / 06期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

SURFACTANT PROTEIN-D; MANNOSE-BINDING LECTIN; DENDRITIC CELLS; FUNCTIONAL CONSEQUENCES; CROSS-PRESENTATION; RECEPTOR DECTIN-1; SIGNALING PATHWAY; ACTIVATION; MINCLE; INFLAMMATION;

D O I：

10.1038/s41577-018-0004-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The C-type lectins are a superfamily of proteins that recognize a broad repertoire of ligands and that regulate a diverse range of physiological functions. Most research attention has focused on the ability of C-type lectins to function in innate and adaptive antimicrobial immune responses, but these proteins are increasingly being recognized to have a major role in autoimmune diseases and to contribute to many other aspects of multicellular existence. Defects in these molecules lead to developmental and physiological abnormalities, as well as altered susceptibility to infectious and non-infectious diseases. In this Review, we present an overview of the roles of C-type lectins in immunity and homeostasis, with an emphasis on the most exciting recent discoveries.

引用

页码：374 / 389

页数：16

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