Role of complement component C5 in cerebral ischemia/reperfusion injury

被引:39
作者
Costa, Cristina
Zhao, Limin
Shen, Yamin
Su, Xiao
Hao, Liming
Colgan, Sean P.
Stahl, Gregory L.
Zhou, Tong
Wang, Yi
机构
[1] Alex Pharmaceut Inc, Dept Preclin Sci, Cheshire, CT 06410 USA
[2] Univ Alabama, Dept Med, Birmingham, AL 35294 USA
[3] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA
[4] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, Boston, MA 02115 USA
[5] Hosp Llobregat, IDIBELL, Barcelona, Spain
关键词
cerebral stroke; middle cerebral artery occlusion; complement component C5; ischemia/reperfusion injury;
D O I
10.1016/j.brainres.2006.05.029
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We evaluated the role of complement component C5 during the course of cerebral ischemic reperfusion injury in a rat model of middle cerebral artery occlusion (MCAO). Systemic CS inhibition was achieved with an anti-C5 monoclonal antibody, which significantly prevented the deterioration of the motor functions by reducing cerebral lesion and edema. Our results show that activated C5 complement components played an important role in cerebral tissue inflammation resulting from ischemia/reperfusion injury. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:142 / 151
页数:10
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