Smoking and the risk of age-related macular degeneration: A meta-analysis

被引:72
作者
Cong, Rihong [1 ]
Zhou, Bo [1 ]
Sun, Qingmin [1 ]
Gu, Haijuan [1 ]
Tang, Naping [1 ]
Wang, Bin [1 ]
机构
[1] Nanjing Med Univ, Dept Pharmacol, Key Lab Reprod Med, Nanjing 210029, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
age-related macular degeneration; geographic atrophy; smoking; meta-analysis;
D O I
10.1016/j.annepidem.2008.04.002
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
PURPOSE: Some studies were undertaken to evaluate the association between cigarette smoking and age-related macular degeneration (AMD). This meta-analysis summarized the risk estimate of smoking and AMD and provided robust evidence for the association. METHODS: Relevant studies were identified by searching PubMed and MEDLINE (from 1966 to June 2007) and reviewing the reference lists of key articles. The summary relative risk ratio (RR) or odds ratio (OR) and 95% confidence interval (CI) were calculated. Study-specific risk estimates were pooled using a random-effects model. RESULTS: Five prospective cohort and eight case-control studies met our inclusion criteria. Ever smoking was statistically significant associated with increased risk of AMD among cohort studies (RR, 1.61; 95% CI, 1.01-2.57) or case-control studies (RR, 1.76; 95% CI, 1.56-1.99). Current smokers were at higher risk of AMD than past smokers. Both geographic atrophy (GA) and neovascular AMD (NV) are subtypes of AMD. A significant relationship was found between smoking and GA risk. Smoking increased the risk of NV, with marginal nonsignificance (RR, 1.47; 95% CI, 0.92-2.37) in cohort studies and significance in case-control studies (RR, 1.96; 95% CI, 1.69-2-27). CONCLUSIONS: This meta-analysis indicated smoking, especially current smoking, was significantly associated with increased risks of AMD and its subtypes.
引用
收藏
页码:647 / 656
页数:10
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