The T cell receptor beta genes of Xenopus

被引:48
作者
Chretien, I [1 ]
Marcuz, A [1 ]
Fellah, J [1 ]
Charlemagne, J [1 ]
DuPasquier, L [1 ]
机构
[1] UNIV PARIS 06,IMMUNOL LAB,PARIS,FRANCE
关键词
TCRB genes; Xenopus; BV family; evolution;
D O I
10.1002/eji.1830270327
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
cDNA of the T cell receptor beta (TCRB) have been isolated from the anuran amphibian Xenopus and they show strong structural homology to TCRB sequences of other vertebrates. Ten BV families, two D segments, ten J segments, and a single C region have been defined so far. Each V family consists of one to two members per haploid genome. A unique feature of the Xenopus TCRB constant region is the lack of N-linked carbohydrate glycosylation sites. The recombination signal sequences suggest that the mechanism of rearrangements are identical to those of mammals. The locus is inherited in a diploid manner despite the pseudotetraploidy of the Xenopus laevis and X. gilli used in this study.
引用
收藏
页码:763 / 771
页数:9
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