Cardiovascular profile of loratadine

被引:10
作者
Hey, JA [1 ]
Affrime, M [1 ]
Cobert, B [1 ]
Kreutner, W [1 ]
Cuss, FM [1 ]
机构
[1] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA
关键词
loratadine; non-sedating antihistamine; cardiovascular;
D O I
10.1046/j.1365-2222.1999.0290s3197.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
The extremely low reporting rate of cardiovascular adverse events for loratadine, the possible preferential use of loratadine in patients with pre-existing cardiovascular disorders, and the impressive lack of cardiovascular effects at extremely high concentrations in clinical and preclinical studies demonstrate the very safe cardiovascular profile of loratadine.
引用
收藏
页码:197 / 199
页数:3
相关论文
共 16 条
[1]   LORATADINE ADMINISTERED CONCOMITANTLY WITH ERYTHROMYCIN - PHARMACOKINETIC AND ELECTROCARDIOGRAPHIC EVALUATIONS [J].
BRANNAN, MD ;
REIDENBERG, P ;
RADWANSKI, E ;
SHNEYER, L ;
LIN, CC ;
CAYEN, MN ;
AFFRIME, MB .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1995, 58 (03) :269-278
[2]  
BRANNAN MD, 1994, J CLIN PHARMACOL, V34, P1016
[3]  
Brannan Melvin D., 1994, Pharmacotherapy, V14, P347
[4]   A MOLECULAR-BASIS FOR CARDIAC-ARRHYTHMIA - HERG MUTATIONS CAUSE LONG QT SYNDROME [J].
CURRAN, ME ;
SPLAWSKI, I ;
TIMOTHY, KW ;
VINCENT, GM ;
GREEN, ED ;
KEATING, MT .
CELL, 1995, 80 (05) :795-803
[5]   Comparative effects of loratadine and terfenadine on cardiac K+ channels [J].
Ducic, I ;
Ko, CM ;
Shuba, Y ;
Morad, M .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1997, 30 (01) :42-54
[6]   ANTIHISTAMINE ACTIVITY, CENTRAL-NERVOUS-SYSTEM AND CARDIOVASCULAR PROFILES OF HISTAMINE H-1 ANTAGONISTS - COMPARATIVE-STUDIES WITH LORATADINE, TERFENADINE AND SEDATING ANTIHISTAMINES IN GUINEA-PIGS [J].
HEY, JA ;
DELPRADO, M ;
CUSS, FM ;
EGAN, RW ;
SHERWOOD, J ;
LIN, CC ;
KREUTNER, W .
CLINICAL AND EXPERIMENTAL ALLERGY, 1995, 25 (10) :974-984
[7]  
Hey JA, 1996, ARZNEIMITTEL-FORSCH, V46, P153
[8]   TERFENADINE-KETOCONAZOLE INTERACTION - PHARMACOKINETIC AND ELECTROCARDIOGRAPHIC CONSEQUENCES [J].
HONIG, PK ;
WORTHAM, DC ;
ZAMANI, K ;
CONNER, DP ;
MULLIN, JC ;
CANTILENA, LR .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 269 (12) :1513-1518
[9]  
Ko CM, 1997, J PHARMACOL EXP THER, V281, P233
[10]   Interactions of the nonsedating antihistamine loratadine with a Kv1.5-type potassium channel cloned from human heart [J].
Lacerda, AE ;
Roy, ML ;
Lewis, EW ;
Rampe, D .
MOLECULAR PHARMACOLOGY, 1997, 52 (02) :314-322