Lifestyle and nutritional determinants of bioavailable androgens and related hormones in British men

被引:125
作者
Allen, NE [1 ]
Appleby, PN [1 ]
Davey, GK [1 ]
Key, TJ [1 ]
机构
[1] Univ Oxford, Radcliffe Infirm, Canc Res UK Epidemiol Unit, Oxford OX2 6HE, England
关键词
androstanediol glucuronide; bioavailable androgens; diet; lifestyle determinants; sex hormones;
D O I
10.1023/A:1015238102830
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objective: To investigate the lifestyle and nutritional determinants of serum bioavailable androgens and their related hormones in men. Methods: This study is based on a sample of 696 men with a wide range of nutrient intakes, whose diet and lifestyle characteristics were assessed with a questionnaire and serum sex hormones measured using immunoassays. Results: Men aged 70 years or older had 12% lower testosterone and 40% lower free-testosterone (FT) and androstanediol glucuronide (A-diol-g) concentrations than men who were 20-29 years of age. Conversely, sex hormone-binding globulin (SHBG) and luteinizing hormone (LH) concentrations were 90% and 49% higher in the oldest age group compared with the lowest, respectively. Men who had a body mass index (BMI) of 30+ kg/m(2) had 30% lower testosterone, 45% lower SHBG, 22% lower LH and 5% lower FT concentrations compared with men with a BMI of < 20 kg/m(2). Conversely, A-diol-g concentration was 15% higher in the highest BMI category compared with the lowest. A high waist circumference was further associated with a 12% lower testosterone and SHBG concentration, after adjusting for BMI. Compared with never-smokers, smoking 10+ cigarettes/day was associated with 15% higher testosterone, 22% higher SHBG and 17% higher LH concentrations; FT and A-diol-g were not associated with smoking. Compared with no exercise, vigorous exercise of 3+ hours/week was associated with 11% higher testosterone and 16% higher SHBG concentrations, whilst LH, FT, and A-diol-g were not associated with vigorous exercise. Dietary factors were not strongly associated with hormones, although saturated fat intake was negatively associated with SHBG (r = -0.10; p = 0.01) and alcohol intake was positively associated with A-diol-g (r = 0.11; p = 0.004). No dietary factors were associated with testosterone, FT, or LH. Conclusions: Age is the strongest determinant of serum bioavailable androgens. BMI and some lifestyle and dietary factors influence SHBG and testosterone concentrations, but have no strong association with FT, suggesting that homeostasis is effective. A-diol-g shows broadly similar associations to FT, with the exception of the effect of BMI and alcohol.
引用
收藏
页码:353 / 363
页数:11
相关论文
共 55 条
[1]   EFFECT OF DIETARY-COMPONENTS, INCLUDING LIGNANS AND PHYTOESTROGENS, ON ENTEROHEPATIC CIRCULATION AND LIVER-METABOLISM OF ESTROGENS AND ON SEX-HORMONE BINDING GLOBULIN (SHBG) [J].
ADLERCREUTZ, H ;
HOCKERSTEDT, K ;
BANNWART, C ;
BLOIGU, S ;
HAMALAINEN, E ;
FOTSIS, T ;
OLLUS, A .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1987, 27 (4-6) :1135-1144
[2]  
Allen DN, 2000, NEUROPSY NEUROPSY BE, V13, P184
[3]   Progressive genetic aberrations detected by comparative genomic hybridisation in squamous cell cervical cancer [J].
Allen, DG ;
White, DJ ;
Hutchins, AM ;
Scurry, JP ;
Tabrizi, SN ;
Garland, SM ;
Armes, JE .
BRITISH JOURNAL OF CANCER, 2000, 83 (12) :1659-1663
[4]   Strong association between serum levels of leptin and testosterone in men [J].
Behre, HM ;
Simoni, M ;
Nieschlag, E .
CLINICAL ENDOCRINOLOGY, 1997, 47 (02) :237-240
[5]   Validation of dietary assessment methods in the UK arm of EPIC using weighed records, and 24-hour urinary nitrogen and potassium and serum vitamin C and carotenoids as biomarkers [J].
Bingham, SA ;
Gill, C ;
Welch, A ;
Cassidy, A ;
Runswick, SA ;
Oakes, S ;
Lubin, R ;
Thurnham, DI ;
Key, TJA ;
Roe, L ;
Khaw, KT ;
Day, NE .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1997, 26 :S137-S151
[6]  
COFFEY DS, 1981, UROLOGY, V17, P17
[7]   Relationship of chronic endurance exercise to the somatotropic and sex hormone status of older men [J].
Cooper, CS ;
Taaffe, DR ;
Guido, D ;
Packer, E ;
Holloway, L ;
Marcus, R .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1998, 138 (05) :517-523
[8]   Endogenous sex hormones and prostate cancer: a quantitative review of prospective studies [J].
Eaton, NE ;
Reeves, GK ;
Appleby, PN ;
Key, TJ .
BRITISH JOURNAL OF CANCER, 1999, 80 (07) :930-934
[9]  
Ellingboe J, 1987, Alcohol Alcohol Suppl, V1, P109
[10]   Effect of cigarette smoking on levels of bioavailable testosterone in healthy men [J].
English, KM ;
Pugh, PJ ;
Parry, H ;
Scutt, NE ;
Channer, KS ;
Jones, TH .
CLINICAL SCIENCE, 2001, 100 (06) :661-665