Renal cancer: Oxygen meets metabolism

被引：25

作者：

Haase, Volker H. ^{[1
,2
,3
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Med, Div Nephrol & Hypertens,MCN,Vanderbilt Sch Med, Nashville, TN 37232 USA

[2] Vanderbilt Univ Sch Med, Dept Canc Biol, Nashville, TN USA

[3] Vanderbilt Univ Sch Med, Dept Mol Physiol & Biophys, Nashville, TN USA

来源：

EXPERIMENTAL CELL RESEARCH | 2012年 / 318卷 / 09期

关键词：

Renal cell cancer; VHL tumor suppressor; Hypoxia-inducible factor; Oxygen; Glucose metabolism; Mitochondria; LINDAU TUMOR-SUPPRESSOR; HYPOXIA-INDUCIBLE FACTOR; CELL CARCINOMA; E-CADHERIN; CYCLIN D1; VHL LOSS; INTERFERON-ALPHA; GENETIC-ANALYSIS; PYRUVATE-KINASE; PRIMARY CILIA;

D O I：

10.1016/j.yexcr.2012.02.026

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Over the last two decades molecular studies of inherited tumor syndromes that are associated with the development of kidney cancer have led to the identification of genes and biochemical pathways, which play key roles in the malignant transformation of renal epithelial cells. Some of these findings have broad biological impact and extend beyond renal cancer. This review's focus is on the von Hippel-Lindau (VHL)/hypoxia-inducible factor (HIF) oxygen-sensing pathway and its role in physiology, energy metabolism and tumorigenesis. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：1057 / 1067

页数：11

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