Serum oxidized low-density lipoprotein level and risk of cognitive impairment in older women

被引：12

作者：

Koyama, Alain ^{[1
,2
]}

Stone, Katie ^{[3
]}

Yaffe, Kristine ^{[2
,4
,5
,6
]}

机构：

[1] No Calif Inst Res & Educ, San Francisco, CA USA

[2] San Francisco VA Med Ctr, San Francisco, CA USA

[3] Calif Pacific Med Ctr, Res Inst, San Francisco, CA USA

[4] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA

[5] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

[6] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

来源：

NEUROBIOLOGY OF AGING | 2013年 / 34卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Dementia; Alzheimer's disease; Oxidized LDL; Inflammation; Oxidative stress; ALZHEIMERS-DISEASE; DEMENTIA; LDL; INFLAMMATION;

D O I：

10.1016/j.neurobiolaging.2012.02.030

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We investigated the association between serum level of oxidized low-density lipoprotein (oxLDL) and risk of cognitive impairment (dementia or mild cognitive impairment) among 572 nondemented community-dwelling women from a prospective cohort study of aging. After 5 years of follow-up, 228 (39.9%) developed cognitive impairment; and this did not differ by tertile of baseline oxLDL level (highest compared with lowest tertile 38.2% vs. 39.5%; odds ratio, 0.90; 95% confidence interval, 0.63-1.43). Multivariate adjustment produced similar results (odds ratio, 0.91; 95% confidence interval, 0.60-1.39). These findings suggest that increased levels of serum oxLDL are not associated with a greater risk of incident cognitive impairment in older women. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：634 / U293

页数：4

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