The Use of TKM-100802 and Convalescent Plasma in 2 Patients With Ebola Virus Disease in the United States

被引：140

作者：

Kraft, Colleen S. ^{[1
,2
]}

Hewlett, Angela L. ^{[3
]}

Koepsell, Scott ^{[4
]}

Winkler, Anne M. ^{[1
]}

Kratochvil, Christopher J. ^{[5
]}

Larson, LuAnn ^{[6
]}

Varkey, Jay B. ^{[2
]}

Mehta, Aneesh K. ^{[2
]}

Lyon, Marshall, III ^{[2
]}

Friedman-Moraco, Rachel J. ^{[2
]}

Marconi, Vincent C. ^{[2
]}

Hill, Charles E. ^{[1
]}

Sullivan, James N. ^{[7
]}

Johnson, Daniel W. ^{[7
]}

Lisco, Steven J. ^{[7
]}

Mulligan, Mark J. ^{[2
]}

Uyeki, Timothy M. ^{[8
]}

McElroy, Anita K. ^{[8
]}

Sealy, Tara ^{[8
]}

Campbell, Shelley ^{[8
]}

Spiropoulou, Christina ^{[8
]}

Stroeher, Ute ^{[8
]}

Crozier, Ian ^{[9
]}

Sacra, Richard ^{[10
]}

Connor, Michael J., Jr. ^{[11
,12
,13
,14
]}

Sueblinvong, Viranuj ^{[11
,12
,13
,14
]}

Franch, Harold A. ^{[14
]}

Smith, Philip W. ^{[3
]}

Ribner, Bruce S. ^{[2
]}

机构：

[1] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

[2] Emory Univ, Sch Med, Div Infect Dis, Dept Med, Atlanta, GA 30322 USA

[3] Univ Nebraska Med Ctr, Div Infect Dis, Dept Internal Med, Omaha, NE USA

[4] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE USA

[5] Univ Nebraska Med Ctr, Off Vice Chancellor Res, Omaha, NE USA

[6] Univ Nebraska Med Ctr, Ctr Clin & Translat Res, Omaha, NE USA

[7] Univ Nebraska Med Ctr, Div Crit Care, Dept Anesthesiol, Omaha, NE USA

[8] Ctr Dis Control & Prevent, Atlanta, GA USA

[9] WHO, Kenema Hosp, Freetown, Sierra Leone

[10] Univ Massachusetts, Sch Med, Worcester, MA USA

[11] Emory Univ, Div Pulm, Atlanta, GA 30322 USA

[12] Emory Univ, Div Allergy, Atlanta, GA 30322 USA

[13] Emory Univ, Div Crit Care, Atlanta, GA 30322 USA

[14] Emory Univ, Renal Med, Dept Med, Atlanta, GA 30322 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2015年 / 61卷 / 04期

基金：

美国国家卫生研究院;

关键词：

TKM-Ebola; convalescent plasma; convalescent serum; Ebola virus; Ebola virus disease; HEMORRHAGIC-FEVER; POSTEXPOSURE PROTECTION; NONHUMAN-PRIMATES; PROPHYLAXIS; CHALLENGE;

D O I：

10.1093/cid/civ334

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. The current West Africa Ebola virus disease (EVD) outbreak has resulted in multiple individuals being medically evacuated to other countries for clinical management. Methods. We report two patients who were transported from West Africa to the United States for treatment of EVD. Both patients received aggressive supportive care measures, as well as an investigational therapeutic (TKM-100802) and convalescent plasma. Results. While one patient experienced critical illness with multi-organ failure requiring mechanical ventilation and renal replacement therapy, both patients recovered without serious long-term sequelae to date. Conclusions. It is unclear what role the experimental drug and convalescent plasma had in the recovery of these patients. Prospective clinical trials are needed to delineate the role of investigational therapies in the care of patients with EVD.

引用

页码：496 / 502

页数：7

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