Crystal Structure of a Ten-Amino Acid Protein

被引：146

作者：

Honda, Shinya ^{[1
]}

Akiba, Toshihiko ^{[1
]}

Kato, Yusuke S. ^{[1
]}

Sawada, Yoshito ^{[1
]}

Sekijima, Masakazu ^{[1
]}

Ishimura, Miyuki ^{[1
]}

Ooishi, Ayako ^{[1
]}

Watanabe, Hideki ^{[1
]}

Odahara, Takayuki ^{[1
]}

Harata, Kazuaki ^{[1
]}

机构：

[1] Natl Inst Adv Ind Sci & Technol, Tsukuba, Ibaraki 3058566, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 46期

关键词：

D O I：

10.1021/ja8030533

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

What is the smallest protein? This is actually not such a simple question to answer, because there is no established consensus among scientists as to the definition of a protein. We describe here a designed molecule consisting of only 10 amino acids. Despite its small size, its essential characteristics, revealed by its crystal structure, solution structure, thermal stability, free energy surface, and folding pathway network, are consistent with the properties of natural proteins. The existence of this kind of molecule deepens our understanding of proteins and impels us to define an "ideal protein" without inquiring whether the molecule actually occurs in nature.

引用

页码：15327 / 15331

页数：5

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