Diversity of vertebrate nicotinic acetylcholine receptors

被引：332

作者：

Millar, Neil S. ^{[1
]}

Gotti, Cecilia ^{[2
]}

机构：

[1] UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England

[2] Univ Milan, Dept Med Pharmacol, Inst Neurosci Cellular & Mol Pharmacol, CNR, Milan, Italy

来源：

NEUROPHARMACOLOGY | 2009年 / 56卷 / 01期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

Acetylcholine receptor; Nicotinic receptor; Receptor diversity; ALPHA-BUNGAROTOXIN RECEPTORS; SUBUNIT COMPOSITION; FUNCTIONAL EXPRESSION; CHOLINERGIC-RECEPTORS; CHICK RETINA; PHARMACOLOGICAL CHARACTERIZATION; DEVELOPMENTAL REGULATION; PARKINSONS-DISEASE; CRYSTAL-STRUCTURE; DOPAMINE RELEASE;

D O I：

10.1016/j.neuropharm.2008.07.041

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nicotinic acetylcholine receptors (nAChRs) are pentameric neurotransmitter receptors. They are members of the Cys-loop family of ligand-gated ion channels which also include ionotropic receptors for 5-hydroxytryptamine (5-HT), gamma-aminobutyric acid (GABA) and glycine. Nicotinic receptors are expressed in both the nervous system and at the neuromuscular junction and have been implicated in several neurological and neuromuscular disorders. In vertebrates, seventeen nAChR subunits have been identified (alpha 1-alpha 10, beta 1-beta 4, gamma, delta and epsilon) which can co-assemble to generate a diverse family of nAChR subtypes. This review will focus on vertebrate nAChRs and will provide an overview of the extent of nAChR diversity based on studies of both native and recombinant nAChRs. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：237 / 246

页数：10

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