Genetic manipulation of insulin signaling, action and secretion in mice - Insights into glucose homeostasis and pathogenesis of type 2 diabetes

被引：32

作者：

Baudry, A ^{[1
]}

Leroux, L ^{[1
]}

Jackerott, M ^{[1
]}

Joshi, RL ^{[1
]}

机构：

[1] Univ Paris 05, INSERM, CNRS, Inst Cochin,Dept Genet Dev & Mol Pathol, F-75014 Paris, France

来源：

EMBO REPORTS | 2002年 / 3卷 / 04期

关键词：

D O I：

10.1093/embo-reports/kvf078

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Non-insulin-dependent diabetes mellitus (NIDDM) is a complex heterogeneous polygenic disease characterized mainly by insulin resistance and pancreatic P-cell dysfunction. In recent years, several genetically engineered mouse models have been developed for the study of the pathophysiological consequences of defined alterations in a single gene or in a set of candidate diabetogenes. These represent new tools that are providing invaluable insights into NIDDM pathogenesis. In this review, we highlight the lessons emerging from the study of some of the transgenic or knockout mice in which the expression of key actors in insulin signaling, action or secretion has been manipulated. In addition to contributing to our knowledge of the specific roles of individual genes in the control of glucose homeostasis, these studies have made it possible to address several crucial issues in NIDDM that have remained controversial or unanswered for a number of years.

引用

收藏

页码：323 / 328

页数：6

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