Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2

被引：232

作者：

Youn, HD

Sun, L

Prywes, R

Liu, JO ^{[1
]}

机构：

[1] MIT, Ctr Canc Res, Cambridge, MA 02139 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

[3] MIT, Dept Chem, Cambridge, MA 02139 USA

[4] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

来源：

SCIENCE | 1999年 / 286卷 / 5440期

关键词：

D O I：

10.1126/science.286.5440.790

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

T cell receptor (TCR)-induced apoptosis of thymocytes is media ted by calcium-dependent expression of the steroid receptors Nur77 and Nor1, Nur77 expression is controlled by the transcription factor myocyte enhancer factor 2 (MEF2), but how MEF2 is activated by calcium signaling is still obscure. Cabin1, a calcineurin inhibitor, was found to regulate MEF2. MEF2 was normally sequestered by Cabin1 in a transcriptionally inactive state. TCR engagement led to an increase in intracellular calcium concentration and the dissociation of MEF2 from Cabin1, as a result of competitive binding of activated calmodulin to Cabin1. The interplay between Cabin1, MEF2, and calmodulin defines a distinct signaling pathway from the TCR to the Nur77 promoter during T cell apoptosis.

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页码：790 / 793

页数：4

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