Kinetic resolution of propranolol by a lipase-catalyzed N-acetylation

被引：45

作者：

Chiou, TW

Chang, CC

Lai, CT

Tai, DF

机构：

[1] ACAD SINICA,INST CHEM,TAIPEI,TAIWAN

[2] DA YEH INST TECHNOL,CTR BIOCHEM ENGN,CHANGHUA,TAIWAN

[3] NATL DONG HWA UNIV,DEPT CHEM,HUALIEN,TAIWAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(97)00028-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An enzymatic method for the direct resolution of propranolol is described. Candida cylindracea lipase enantioselectively catalyzed N-acetylation of S-propranolol with isopropenyl acetate in isopropyl ether, The ee values of the two enantiomers of N-acetylpropranolol were determined by an HPLC equipped with a chiral column. The effects of organic solvent nature and substrate concentration on enantioselectivity were also studied. (C) 1997, Elsevier Science Ltd.

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页码：433 / 436

页数：4

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