Controlled autocatalytic nitration of phenol in a microreactor

被引：126

作者：

Ducry, L ^{[1
]}

Roberge, DM ^{[1
]}

机构：

[1] Lonza Ltd, Valais Works, CH-3930 Visp, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 48期

关键词：

autocatalysis; microreactor; nitration; oxidation; synthetic methods;

D O I：

10.1002/anie.200502387

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Scaled-down approach: The nitration of phenol is an autocatalytic, strongly exothermic reaction and is thus difficult to handle on an industrial scale. Continuous nitration in a microreactor (see picture) affords higher yields and enhanced process safety, thanks to good heat exchange and mixing properties, as well as rapid radical propagation under sufficiently harsh conditions. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7972 / 7975

页数：4

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