Anti-MPO-ANCA-positive microscopic polyangiitis following subacute bacterial endocarditis

被引：35

作者：

Hellmich, B ^{[1
]}

Ehren, M ^{[1
]}

Lindstaedt, M ^{[1
]}

Meyer, M ^{[1
]}

Pfohl, M ^{[1
]}

Schatz, H ^{[1
]}

机构：

[1] Ruhr Univ Bochum, Klin Bergmannsheil, Poliklin Rheumatol, Med Klin & Poliklin, D-44702 Bochum, Germany

来源：

CLINICAL RHEUMATOLOGY | 2001年 / 20卷 / 06期

关键词：

antineutrophil cytoplasmic antibodies; bacterial endocarditis; microscopic polyangiitis; vasculitis;

D O I：

10.1007/PL00011214

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although infectious agents such as Staphylococcus aureus have been implicated in the pathogenesis of Wegener's granulomatosis, the role of bacterial infections in the pathogenesis of other types of small-vessel vasculitides associated with antineutrophil cytoplasmic antibodies (ANCA) is less clear. We describe a patient who developed a non-granulomatous necrotising small vessel vasculitis and perinuclear ANCA (p-ANCA) directed against myeloperoxidase (MPO) after recurrent episodes of bacterial endocarditis due to Staph. aureus. Although cytoplasmic ANCA (c-ANCA) directed against proteinase 3 have been reported in single patients with bacterial endocarditis, to our knowledge this patient is the first reported case of an anti-MPO-ANCA positive systemic vasculitis following bacterial endocarditis.

引用

页码：441 / 443

页数：3

共 17 条

[1] Microscopic polyangiitis (microscopic polyarteritis) with late emergence of generalised Wegener's granulomatosis [J].