The Evidence Dilemma In Genomic Medicine

被引：83

作者：

Khoury, Muin J. ^{[1
]}

Berg, Al ^{[2
]}

Coates, Ralph

Evans, James ^{[3
]}

Teutsch, Steven M. ^{[4
]}

Bradley, Linda A. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Natl Off Publ Hlth Genom, EGAPP, Atlanta, GA 30333 USA

[2] Univ Washington, Seattle, WA 98195 USA

[3] Univ N Carolina, Chapel Hill, NC USA

[4] Merck & Co Inc, West Point, PA USA

来源：

HEALTH AFFAIRS | 2008年 / 27卷 / 06期

关键词：

D O I：

10.1377/hlthaff.27.6.1600

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

An ongoing dilemma in genomic medicine is balancing the need for scientific innovation with appropriate evidence thresholds for moving technology into practice. The current low threshold allows unsubstantiated technologies to enter into practice, with the potential to overwhelm the health system. Alternatively, establishing an excessively high threshold for evidence could slow the integration of genomics into practice and present disincentives for investing in research and development. Also, variable coverage and reimbursement policies can lead to differential access to technology, exacerbating health disparities. There is an urgent need for a collaborative process for appropriate transition of genomic discoveries from research to practice. [Health Affairs 27, no. 6 (2008): 1600 1611; 10.1377/hlthaff.27.6.1600]

引用

页码：1600 / 1611

页数：12

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